Groundbreaking new topical treatment for Atopic Dermatitis (Eczema)

June 4, 2016, Featured in Immunotherapy, 0 Comments

There are different types of eczema. The most common type is atopic dermatitis (AD). AD is a chronic, pruritic, inflammatory skin condition that is associated with immune dysregulation and epidermal barrier dysfunction. The most obvious symptoms of AD are intense itching, along with red, dry skin that is sometimes scaly. The severity can range from mild to severe. It usually starts in early childhood. Most cases first develop in children under the age of 5 years. It is unusual to develop AD for the first time after the age of 20. At the moment, about 1 in 5 schoolchildren have some degree of AD. However, statistics show that it is becoming more common year on year in developed countries. There is no cure but treatment can usually control or ease symptoms, and treatment options are limited. About 2 in 3 children with AD grow out of it by their mid-teens.

The word ‘atopic’ describes people with certain allergic tendencies. However, AD is not just a simple allergic condition. People with AD have an increased chance of developing other atopic conditions, such as asthma and  hay fever. Typically, inflamed area of skin tend to flare up from time to time and then tend to settle down. The severity and duration of flare-ups varies from person to person and from time to time in the same person. The cause is not known but factors which may play a part include:

  • Diet
  • Pollution
  • Infections
  • Allergies to house dust mite or pollens
  • Other early-life factors
  • Stress and habit scratching
  • Moulds, and dander from pets
  • Pregnancy and hormonal changes before a period in women

Skin is the largest body organ and is equipped with metabolic and endocrine capabilities that facilitate homeostatic control between internal and external environments. The outermost layer of skin, stratum corneum (SC), functions as the major barrier to diffusion. The main components of the SC extracellular lipid system are ceramides, free fatty acids and cholesterol. The lipid barrier of the skin tends to be reduced in people with AD. This leads to an increase in water loss and a tendency towards dry skin. The loss of skin barrier function means that:

  • Important water is lost through the damaged skin
  • Irritants many penetrate (Soap,  detergent, solvents, dirt etc.)
  • Allergens may penetrate it (pollens, dust-mite antigens, microbes)

The specialized immune cells of the epidermis (Langerhans cells) in AD have an increased response to these antigens and interact with dermal T cells to produce a Th2 response. The inflammation induced by this Th2 response exacerbates the barrier defect.

  • Ceramide (a fatty acid) is lost
  • Filaggrin (the skin’s glue) is reduced
  • Antimicrobial peptides are reduced
  • Bacteria colonise and infect the skin
  • Infections are more difficult to control

Also, some inflammatory cells release cytokines under the skin surface, which can cause some inflammation. The immune system develops in the first 6 months of life. There is a generally an equilibrium of the two main types of the T helper lymphocytes, Th1 and Th2. Patients with AD have poor immune cell function and a predominance of Th2-type cytokine response when their lymphocytes are activated. A Th2-type response, which is characterized by production of cytokines. In AD, various factors contribute to a high-Th2/low-Th1 cell environment. In the cutaneous inflammation associated with  AD, not only activated T cells (Th2 and Th1), but also other inflammatory cells are known to be involved in a complex manner. In some children with AD, there are also high levels of IgE antibodies and eosinophils (the white blood cells associated with allergy).  The imbalance of the Th2 and Th1 pathways and their associated cytokines in AD presents as one facet of the pathogenic mechanisms. In general, the treatment of the AD can be roughly categorized into treatment of existent  cutaneous inflammation and prevention of new inflammation. It is important to achieve rapid remission of inflammation.

Cellular and molecular mechanisms in atopic dermatitis.

The Atopic March: Progression from Atopic Dermatitis to Allergic Rhinitis and Asthma.

Prevention of food allergy.

Atopic dermatitis results in intrinsic barrier and immune abnormalities: implications for contact dermatitis.

The clinical relevance of maintaining the functional integrity of the stratum corneum in both healthy and disease-affected skin.

The potential role of impaired Notch signalling in atopic dermatitis.

Does therapeutic intervention in atopic dermatitis normalize epidermal Notch deficiency?

Biological Treatments in Atopic Dermatitis.

Review on Immunomodulation and Immunomodulatory Activity of Some Herbal Plants

Thus, the best remedy for AD is the use of natural topical immunomodulators with natural skin moisturizing and rejuvenating properties. Herbs, oils and minerals have been used in medicines and cosmetics from centuries. Their potential to treat different skin diseases, to adorn and improve the skin appearance is well-known. Herbal immunomodulators are also used when the immune system is over-active, as in allergies and auto-immunity.

A revolutionary new AD treatment is a lipid-based topical immunomodulator (Atozym) aimed at modulating an immune system imbalance (Th2/Th1) and repairing the SC barrier function lost in AD. Atozym is a natural product. In clinical trials, Atozym has been used as monotherapy for moderate to severe AD in an intermittent fashion, so that treatment is started when the signs of inflammation such as a itch,  dry and inflamed skin are present and flares occur. Atozym showed far superior efficacy to the topical corticosteroids. Moderate to severe AD usually needs long-term treatment. However, treatment with Atozym usually works very well to ease symptoms within a week. It also greatly reduces inflammation. Atozym has been shown to have powerful anti-inflammatory effects, among a number of actions. It also reduces tissue destruction during inflammatory reactions by a number of means. Atozym has been shown to improve skin barrier function and even to mitigate dermal or epidermal atrophy induced by corticosteroids. Atozym is the most effective topical therapy for diverse types of atopic dermatitis flares and severe recalcitrant AD. It can be used on dry lichenified lesions, and also work well to dry weeping or oozing (crusting) lesions. We have to stop thinking that chemical drugs can solve our problems. If you use Atozym, you will see the difference as the healing process starts to take over.

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