CurcuZym contains an “adaptogenic” mixture of fermented herbal compounds including Curcumin C3 complex and Piperine in a synergistic proprietary formula designed to promote anti-cancer and anti-inflammatory effects. Curcumin C3 complex supplies 95% total curcuminoids, including curcumin, bisdemethoxy curcumin and demethoxy curcumin. Piperine is an extract of Black Pepper fruit that contains 95-98% piperine. Piperine is added as a natural bioenhancer to promote absorption and anti-cancer effects.
Curcumin (also known as curcumin I) occurs naturally in the rhizome of Curcuma longa, which is grown commercially and sold as turmeric, a yellow–orange dye. Turmeric contains curcumin along with other chemical constituents known as the “curcuminoids”. The major curcuminoids present in turmeric are demethoxycurcumin (curcumin II), bisdemethoxycurcumin (curcumin III), and the recently identified cyclocurcumin. CurcuZym contains curcumin I (77%), curcumin II (17%), and curcumin III (3%) as its major components. Several analogues of curcumin have been identified from other plant sources. These include 6- and 8-gingerol, 6-paradol, cassumunin, galangals, diarylheptanoids, yakuchinones, isoeugenol, and dibenzoylmethane. Like curcumin, gingerol, paradol, cassumunin, shogaol, and diarylheptanoids are also derived from the roots of the plant. Although most of these analogues exhibit activities very similar to curcumin, whether they are more potent or less potent than curcumin has not been established.
Curcumin is well known to stimulate programmed cell death in cancer and leukemia cells. The list of pathways affected by curcumin seems almost endless. Curcumin is also known to induce oxidative stress in cancer cells. How does curcumin induce oxidative stress? Right now, we only know of two pathways. First, curcumin inhibits the activation of NF-kB. NF-kB promotes the synthesis of many anti-oxidant enzymes. The inhibition of NF-kB activity does not generate ROS (reactive oxygen species). It simply prevents them from being neutralized. The second pathway involves the direct induction of ROS. Curcumin directly binds to thioredoxin reductase and irreversibly changes its activity from an anti-oxidant to a strong prooxidant.
Curcumin has also been cited as a histone deacetylase inhibitor. This should result in increased histone acetylation. The effect of curcumin on the biochemistry of a cell are complex. Curcumin could promote hypoacetylation (inactivation) of certain genes, such as those associated with pro-inflammatory hormones, while simultaneously promoting the hyperacetylation (activation) of tumor suppressor genes. This should activate tumor suppressor genes. In retrospect, this makes perfect sense. If curcumin was strictly a histone deacetylase inhibitor, this would result in the hyperacetylation and activation of pro-inflammatory genes. For cancer, this would be a disaster. Inflammation is the cause of many cancers.
Curcumin is well known to be an anti-inflammatory natural medicine. Curcumin inhibits the activation of NF-kB. The proteasome is an enzyme complex that serves two basic purposes. First, it degrades unwanted proteins. Second, it processes larger, largely inactive proteins into smaller active ones. Inhibiting the proteasome could induce a wide spread programmed cell death in cancer cells. For example, the dreaded Cox-2 enzyme is degraded in the proteasome. Curcumin promotes this degradation. Many cellular growth proteins have a half life of minutes before they are degraded in the proteasome. If these growth factors are allowed to accumulate, growth control will rapidly become dysfunctional. In retrospect, many of curcumin’s clinical properties may be due to its ability to promote proteasome activity.
Unfortunately dietary curcumin in supplement form didn’t help cancers due to low solubility and bioavailability. There are several pharmacokinetic studies about curcumins low solubility and bioavailability, which means that most of what we swallow goes directly into our gastrointestinal area and is expelled. Very little remains in the bloodstream about an hour or so after ingestion. However, CurcuZym contains active curcumin in perfectly bio-available form. CurcuZym is the only product that has perfect bioavailability of curcumin enough to induce apoptosis in cancer cells. Otherwise, curcumin wouldn’t have worked. CurcuZym is synergistic with ChemoZym, GenisZym and other Cancer Remedy Products against cancer and leukemia.
CurcuZym Contains: Proprietary blend of >95% Curcumin C3 complex 228 g (Bisdemethoxy curcumin 6.5%, Demethoxy curcumin 25%, Curcumin 68.5%), Piperine (Black Pepper Fruit Extract) 120 mg, Plant Enzymes, Natural Phyto-compounds
Free of alcohol, soy, corn, gluten, dairy, egg, and is formulated without the use of artificial preservatives, flavors or colors. 100% Pure & Natural
SCIENCE BASED BIOAVAILABILITY
Bioactive CurcuzymTM greatly improve the cellular uptake of Curcumin C3 Complex, the healthful extract from turmeric roots, with clinically validated efficacy in inflammatory conditions. It is recognized that the therapeutic effectiveness of curcumin is limited due to its poor absorption from the GI tract, so the use of the natural fermentation to enhance its uptake is particularly beneficial.