GenisZym is made from high purity genistein (purity 40%) and EGCG (purity 94% ) fermented with a natural, proprietary process. Genistein, an isoflavone derivative related to coumarin, is found in soy products and holds great promise as a natural cancer preventative. There are a number of isoflavones in soy products, but research has shown that genistein is the most potent inhibitor of the growth and spread of cancerous cells.
Genistein is primarily an estrogen antagonist. On a molecule to molecule comparison, genistein activates the estrogen receptor 10,000 to 50,000 times less effectively than estrogen. If a woman is diagnosed with an estrogen responsive cancer, she should immediately begin taking GenisZym and BroccoZym. Synthetic drugs are not necessary. In addition, genistein is a general tyrosine kinase inhibitor, which means it inhibits the activity of the growth promoting EGF and HER-2 receptors. On the other hand, genistein is a multifunctional inhibitor of cancer cell growth. It induces apoptosis in virtually every cancer cell tested. Genistein is one of the best natural anti-cancer compounds yet identified. It kills cancer cells on so many different fronts that it is difficult, if not impossible, to keep abreast of new scientific developments. Genistein is a double edge sword for the treatment of cancer. At low concentrations, it can promote cancer cell growth. At high concentrations, it can kill cancer and leukemia cells in probably 50 different ways.
When cell divide, the ends of the DNA, called telomeres, shorten after every cell division. Eventually, this leads to the death of the cell. Pure and simple, this is a fundamental aspect of normal cell aging. The enzyme telemerase repairs the damaged DNA, thereby increasing the lifespan of the cells. Normal cells contain very low levels of this enzyme. Cancer cells, on the other hand, all cancer cells, contain very high levels. This allows cancer cells to escape one of the major aging controls. Cancer cells have very short telomeres. The only thing keeping these cells alive is their over expression of the enzyme telomerase. Once the ends of the DNA shorten to a prescribed length, the cells will die by programmed cell death. So inhibition of telomerase activity is a major goal of the natural cancer treatment. Genistein is a potent inhibitor of the synthesis and activation of telomerase enzymes
In addition to inhibiting the synthesis of the telomerase enzyme, genistein also inactivates previously synthesized telomerase enzymes. As it turns out, the enzyme AKT, phosphorylates and activates the telomerase enzyme. AKT is an enzyme that plays a critical role in growth control. It is activated by the PI-3K signaling pathway. The AKT enzyme is responsible for the activation of aerobic glycolysis, the metabolic pathway which typifies cancer cell growth. AKT plays many roles in promoting cellular growth/survival. Genistein inhibits AKT activity by different biochemical pathways. Genistein also activates the PTEN tumor suppressor gene. The activation of the PTEN gene by low level of genistein inhibits AKT signaling and the activation of the telomerase enzyme. Genistein, via its inactivation of AKT signaling, can also downregulate NF-kB activity.
Many cancer cells are characterized by increased glycolysis and decreased respiration, even under aerobic conditions. HIF-1(hypoxia-inducible factor-1) negatively regulates mitochondrial bio-genesis and O2 consumption in cancer cells lacking the von Hippel-Lindau tumor suppressor (VHL). HIF-1 mediates these effects by inhibiting C-MYC activity. Genistein could also suppress HIF-1 expression in a concentration-dependent manner. Chemo drugs, over time, induce their own resistance. This resistance takes many forms, but an increase in NF-kB activation is always reported. NF-kB stimulates the synthesis of VEGF(vascular endothelial growth factor), pro-inflammatory hormones and anti-apoptosis survival factors. NF-kB also activates the dreaded Cox-2 gene. Genistein blocked the TNF(tumor necrosis factor) induced NF-kB activation in human volunteers and significantly enhances the anti-cancer effectiveness of chemo drugs.
EGCG (epigallocatechin-3- gallate) from green tea is a great antidote to the cancer-causing effect by synthetic or bio-identical estrogen. EGCG is one class of a larger group of protective phyto-chemicals. Phyto-chemicals are natural chemicals widely distributed in plants. That is why eating more fruits and vegetables, in whatever form, is a great way to prevent cancers. Extracts of green tea have been shown to prevent cancer in animals, and recently similar claims have been made about black tea. All true tea comes from the same plant species (Camellia sinensis), such as black tea, pu-erh tea, and oolong- tea, so they should contain the same amount of EGCG.
Green tea is high in the EGCG which helps prevent the body’s cells from becoming damaged and prematurely aged. Studies have suggested that the combination of GENISTEIN and EGCG may also be beneficial by providing protection against certain types of cancers, including breast cancer. A new study finds that consuming EGCG significantly inhibits breast tumor growth. These results bring us one step closer to better understanding the disease and potentially new and naturally occurring therapies.
Unfortunately both dietary genistein and EGCG in supplement form didn’t help cancers at all due to extremely low solubility and bioavailability. There are several pharmacokinetic studies about EGCG and genistein’s low solubility and bioavailability, which means that most of what we swallow goes directly into our gastrointestinal area and is expelled. In order to introduce pure EGCG and genistein into the blood via absorption and maximize the activity in the body, you could use GenisZym. GenisZym is the one and only product in the world that has perfect solubility/bioavailability of both EGCG and genistein enough to induce apoptosis of the cancer cells. Otherwise, EGCG and genistein wouldn’t have worked. GenisZym is synergistic with BroccoZym, ButterZym, CurcuZym and ChemoZym against cancer and leukemia.