Many fruits and vegetables have nutrients that kill cancer cells and/or stop the spread of cancer. In the context of a cancer diet, to fight cancer, do not use a random selection of vegetables and fruits, but a very selective subset of vegetables and fruits specifically selected to treat cancer because there are food diets perfectly capable of curing cancer. The following 5 foods have the most powerful ability to help stave off cancer and some can even help inhibit cancer cell growth or reduce tumor size.

Black Seeds

Black cumin (Nigella sativa) is a part of the buttercup family and the seeds are dark, thin, and crescent-shaped when whole. The seeds have been used for many centuries in the Middle East, the Mediterranean and India. Today, black cumin seeds are used as a seasoning spice in different cuisines across the world due to their nutty flavor. Besides their culinary uses, black seeds also have a wealth of important health benefits and are one of the most cherished medicinal seeds in history. Nigella sativa and its black seed are known by other names, varying between places. Some call it black caraway, others call it Black Cumin (Kalonji), or even coriander seeds.

Many active components have been isolated from black cumin, including thymoquinone, thymohydroquinone, dithymoquinone, thymol, carvacrol, nigellimine-N-oxide, nigellicine, nigellidine and alpha-hederin. In addition, quite a few pharmacological effects of black cumin seed, its oil, various extracts and active components have been identified to include immune stimulation, anti-inflammation, hypoglycemic, antihypertensive, antiasthmatic, antimicrobial, antiparasitic, antioxidant and anticancer effects. Researchers have discovered that thymoquinone can remedy one of the most virulent and difficult to treat cancers: pancreatic cancer. Black Seeds extract does this by blocking pancreatic cell growth, and actually enhancing the built-in cellular function that causes programmed cell death, or apoptosis. Black seeds have also been found to be especially useful in the treatment of breast, lung, prostate and liver cancer.

Anticancer activity of Nigella sativa (black seed) – a review.

Effects of thymoquinone in the expression of mucin 4 in pancreatic cancer cells: implications for the development of novel cancer therapies.

Structure-activity studies on therapeutic potential of Thymoquinone analogs in pancreatic cancer.

Anti-inflammatory effects of the Nigella sativa seed extract, thymoquinone, in pancreatic cancer cells.

Modulation of apoptosis in human hepatocellular carcinoma (HepG2 cells) by a standardized herbal decoction of nigella sativa seeds, hemidesmus indicus roots and smilax glabra rhizomes with anti- hepatocarcinogenic effects.

Radiosensitization in human breast carcinoma cells by thymoquinone: role of cell cycle and apoptosis.

Thymoquinone up-regulates PTEN expression and induces apoptosis in doxorubicin-resistant human breast cancer cells.

Review on molecular and therapeutic potential of thymoquinone in cancer.

Thymoquinone and cisplatin as a therapeutic combination in lung cancer: In vitro and in vivo.

Studies on molecular mechanisms of growth inhibitory effects of thymoquinone against prostate cancer cells: role of reactive oxygen species.

Nigella sativa modulates splenocyte proliferation, Th1/Th2 cytokine profile, macrophage function and NK anti-tumor activity.

Broccoli seeds and sprouts

A diet high in cruciferous vegetables such as broccoli has been linked to a significant reduction in the risk of cancer, especially prostate cancer, breast cancer, colon cancer, ovarian cancer, and bladder cancer. Broccoli contains glucoraphanin, which with the body processes into the anti-cancer compound sulforaphane. This compound rids the body H. pylori, a bacterium found to highly increase the risk of gastric cancer. Sulforaphane has also been found to be especially useful in the treatment of stomach and bladder cancer.

Furthermore, broccoli contains indole 3 carbinol, a powerful antioxidant compound and anti-carcinogen found to not only hinders the growth of breast, cervical and prostate cancer, but also boosts liver function.

PEITC (Phenethyl isothiocyanate) is an anti-cancer compound found in many vegetables like broccoli, brussels sprouts, cauliflower, kale, etc. Combined, they are an excellent protocol for preventing and treating prostate and breast cancer.

Sulforaphane enhances protection and repair of gastric mucosa against oxidative stress in vitro, and demonstrates anti-inflammatory effects on Helicobacter pylori-infected gastric mucosae in mice and human subjects.

Dietary sulforaphane-rich broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans.

Organ-specific exposure and response to sulforaphane, a key chemopreventive ingredient in broccoli: implications for cancer prevention.

Targets for indole-3-carbinol in cancer prevention.

Broccoli-derived phytochemicals indole-3-carbinol and 3,3′-diindolylmethane exerts concentration-dependent pleiotropic effects on prostate cancer cells: comparison with other cancer preventive phytochemicals.

Inhibition of fatty acid synthase and Sp1 expression by 3,3′-diindolylmethane in human breast cancer cells.

Phenethyl isothiocyanate (PEITC) promotes G2/M phase arrest via p53 expression and induces apoptosis through caspase- and mitochondria-dependent signaling pathways in human prostate cancer DU 145 cells.

Chemopreventative potential of the cruciferous vegetable constituent phenethyl isothiocyanate in a mouse model of prostate cancer.

Differential induction of apoptosis in human breast cancer cell lines by phenethyl isothiocyanate, a glutathione depleting agent.

http://lpi.oregonstate.edu/infocenter/phytochemicals/isothio/

Eggplant Extract

An ingredient in common eggplant has been shown to cure cancer. The eggplant extract is a phytochemical called solasodine glycoside, or BEC5. BEC5 works by bonding to a receptor on the surface of the cancer cell. After the cell digests the eggplant extract, it causes the cell to rupture. The cancer cell is destroyed and its contents are then reabsorbed by the body. BEC5 has been proven effective in treating many cases of skin cancer, preventing surgery. The types of cancer treated by eggplant are both invasive and non-invasive non-melanoma skin cancers. In every case the cancers went into remission and did not return. BEC5 acts by killing cancer cells without harming any other healthy cells in the human body. Eggplant has also been found to be especially useful in the treatment of colon and liver cancer.

http://www.curadermbec5.com/The%20Eggplant%20Cancer%20Cure.pdf

Solasodine glycoalkaloids: a novel topical therapy for basal cell carcinoma. A double-blind, randomized, placebo-controlled, parallel group, multicenter study.

Glycoalkaloids and metabolites inhibit the growth of human colon (HT29) and liver (HepG2) cancer cells.

Green Coffee Bean Extract

Coffee might have anti-cancer properties. Researchers found that coffee drinkers were 50% less likely to get liver cancer than nondrinkers. A few studies have found ties to lower rates of colon, breast, and rectal cancers. There are a number of phytochemicals, the most predominate being chlorogenic acid, that provide coffee’s disease-protecting punch. Of interest is the additional ability of coffee polyphenols to exert direct biological actions on cells. For instance, daily coffee intake may modify key enzymes that improve intracellular signaling, which can protect against diabetes, cancer, and many other diseases. Poor cell signaling may be a factor in cancer, diabetes, and more. Chlorogenic acid, caffeic acid, phytoestrogens, and caffeine – all found in coffee – are suspected of playing a major role.

Chlorogenic acid is a phenolic natural product isolated from the coffee bean. Structurally, chlorogenic acid is the ester of caffeic acid with the 3-hydroxyl group of quinic acid. Chlorogenic acid is an important factor in plant metabolism. It is also an antioxidant and an inhibitor of the tumor promoting activity of phorbol esters. The difference between green coffee beans and regular coffee beans is that one type is raw and unroasted and the other type has undergone the roasting process. Green coffee beans naturally contain higher chlorogenic acid. Roasting coffee beans destroys the cholorgenic acid. By using the unroasted green coffee bean extract, the concentration of chlorogenic acid is higher than could ever be reached drinking regular coffee.

Researchers found a way to extract the chlorogenic acid from the coffee beans without carrying over the high caffeine content. The result is a pure green coffee bean extract rich in chlorogenic acid and low in caffeine. Green coffee bean extract has been advocated for its anti-oxidant, anti-inflammatory, anti-obesity, and anti-cancer properties.

Coffee consumption and risk of cancers: a meta-analysis of cohort studies.

Coffee consumption and prostate cancer risk and progression in the Health Professionals Follow-up Study.

Coffee consumption modifies risk of estrogen-receptor negative breast cancer.

Influence of coffee drinking on subsequent risk of hepatocellular carcinoma: a prospective study in Japan.

Antiproliferation effect of commercially brewed coffees on human ovarian cancer cells in vitro.

Inhibition of DNA methylation by caffeic acid and chlorogenic acid, two common catechol-containing coffee polyphenols.

Caffeic acid, a phenolic phytochemical in coffee, directly inhibits Fyn kinase activity and UVB-induced COX-2 expression.

Coffee phenolic phytochemicals suppress colon cancer metastasis by targeting MEK and TOPK.

Involvement of ROS in chlorogenic acid-induced apoptosis of Bcr-Abl+ CML cells.

The chemopreventive properties of chlorogenic acid reveal a potential new role for the microsomal glucose-6-phosphate translocase in brain tumor progression.

Asparagus Extract

Asparagus (Asparagus officinalis L.) is packed with nutrients, such as folic acid and vitamin E. In addition, it contains high levels of rutin (a flavonoid), protodioscin (a steroidal saponin), asparaginase (an enzyme that catalyzes the hydrolysis of asparagine to aspartic acid), and asparagosides (steroidal glycosides) found in asparagus crowns, spears and roots. Wild asparagus (Asparagus racemosus) is a species of asparagus with a long history of use in Asia as a botanical medicine. Many medicinal qualities of wild asparagus have been associated with phytonutrients present in its roots.

Asparagus has several biological activities including antifungal, antiviral and anticancer activities due to the steroidal saponins, steroidal glycosides and natural enzymes (pharmaceutical companies do not use asparagus as a source of the asparaginase enzyme, but rather, rely on bacteria as their enzyme production source).

Asparagus helps fight chronic fatigue syndrome, helps treat toothaches, helps chelate heavy metals from the body, heals blood vessels, is a diuretic, laxative, antidepressant and an aphrodisiac, and is a wonderful anticancer food. Asparagus can aid weight loss, boost energy, enhance the immune system, make certain vaccines more effective and destroy some types of tumor cells, particularly liver, lung and blood cancers. A recent study showed that asparanin A, a steroidal saponin extracted from asparagus induces cell cycle arrest and triggers apoptosis via a p53-independent manner in liver cancer cells.

Steroidal saponins from Asparagus officinalis and their cytotoxic activity.

Steroids from the roots of Asparagus officinalis and their cytotoxic activity.

http://www.springerlink.com/content/wn3l463kqu454007/

Protodioscin (NSC-698 796): its spectrum of cytotoxicity against sixty human cancer cell lines in an anticancer drug screen panel.

Apoptosis inducing activity of steroidal constituents from Solanum xanthocarpum and Asparagus racemosus.

A novel sarsasapogenin glycoside from Asparagus racemosus elicits protective immune responses against HBsAg.

Immunomodulatory activity of Asparagus racemosus on systemic Th1/Th2 immunity: implications for immunoadjuvant potential.

Asparanin A induces G(2)/M cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells.

Anti-tumor activity of the crude saponins obtained from asparagus.

A new steroidal saponin from the dried stems of Asparagus officinalis L.

Use of L-asparaginase in childhood ALL.

Asparaginase revisited.

Secondary Metabolites from Plants Inhibiting ABC Transporters and Reversing Resistance of Cancer Cells and Microbes to Cytotoxic and Antimicrobial Agents.

An observational study and quantification of the actives in a supplement with Sambucus nigra and Asparagus officinalis used for weight reduction.

Hypolipidemic effect of n-butanol Extract from Asparagus officinalis L. in mice fed a high-fat diet.

Asparagus officinalis extract controls blood glucose by improving insulin secretion and β-cell function in streptozotocin-induced type 2 diabetic rats.

What is BBEGA-Zym?

BBEGA-Zym is a proprietary blend of fermented Black seeds, Broccoli seeds, Eggplant extracts, Green coffee bean extracts, Asparagus extracts and plant based anticancer enzymes. But BBEGA-Zym uses no ordinary fermentation process. BBEGA-Zym is much more effective than your typical cancer fighting supplements or medications. If someone is in a very bad state, in the end stage of their battle, use BBEGA-Zym as the “cancer diet”. BBEGA-Zym can be used alone or in combination with chemotherapy drug or targeted drug. BBEGA-Zym has been successfully tested in recent years in S. Korea as an adjunct to chemotherapy. BBEGA-Zym is not only the most powerful anti-cancer food on the planet, it is also the most nutrient-dense of all vegetables.

BBEGA-Zym shows the greatest synergistic effect when used in combination with Red PalmZym (fermented organic red palm oil), BosturZym Spread, YogurtZym (probiotic fermented wild mushroom ectracts), and HerbalZym Mineral (powerful liquid mineral for killing cancer). With this simple, natural remedy, many surgeries for cancer might be prevented and health restored. The cancer diet is just as important as the cancer treatment. In fact, many cancer patients have cured their cancer by using nothing but a cancer diet.

Your mouth is a jungle! Like everywhere else in your body, your mouth is loaded with billions of bacteria constantly on the move. While some bacteria are harmless, others can attack the teeth and gums. Harmful bacteria are contained in a colorless sticky film called plaque, the cause of gum disease. If not removed, plaque builds up on the teeth and ultimately irritates the gums and causes bleeding. Left unchecked, bone and connective tissue are destroyed, and teeth often become loose and may have to be removed. Gum disease is not just a matter of oral discomfort, bad breath and loose teeth, but in fact it can also affect other parts of your body including some internal organs such as pancreas and heart.

If you’re dedicated to following a pretty good oral care routine and still have stained (or yellow) teeth and bad breath, you may have a bacterial imbalance in your mouth. Other signs that bad bacteria are gaining a strong foothold include poor tooth and gum health and bleeding gums. The harmful and beneficial bacteria in your mouth are directly at odds with one another. They compete for space on the teeth and food. If the bad bacteria are winning that war, one way you’ll know is in the smell of your breath. The harmful bacteria that reside in the mouth produces volatile sulfur compounds (VOCs) which are best known for their rotten-egg smell. Now, your breath doesn’t have to smell like rotten eggs to know that bad bacteria and VOCs are causing foul play. Bad breath is a sign that things are not right, and one simple way to rectify the situation is to address the bacterial imbalances in your mouth.

What exactly are probiotics?

Probiotics are live microorganisms that when administered in adequate amounts confer a health benefit on the host. The human body is teeming with bacteria and other microorganisms. Some bacteria are good for you. Unfortunately, some cause harm, even infection and disease. The most commonly referred bacteria in the probiotic category are Lactobacillus acidophilus. However, there are many other beneficial strains. Research has shown that not only are probiotics beneficial for digestive and immune health, they can also affect your oral health.

What are oral probiotics?

The human mouth is awash with bacteria. More than 700 species thrive in the hot, moist conditions, including Streptococcus mutans, one of the main components of plaque. Clinging to the teeth in thin layers called biofilms, S. mutans digests sugars and produces acids that can eat into enamel and cause cavities.

Oral probiotics protect against the bacteria that cause inflamed tissue, tooth and tissue decay and bad breath. Oral probiotics can protect your mouth, gums, teeth and throat from cavities, gum discomfort, sore throats, biofilm on your tongue, bad breath and even ear discomfort. Probiotics kill the bacteria, like h.pylori that cause ulcers and bad breath. This is done by making hydrogen peroxide.

In oral cavity, probiotics can create a biofilm, acting as a protective lining for oral tissues against oral diseases. Such a biofilm keeps bacterial pathogens off oral tissues by filling a space pathogens would invade in the absence of the biofilm and competing with cariogenic bacteria and periodontal pathogens growth.

Probiotics can reduce the risk for a high Streptococcus mutans level occurrence. An in vitro study has suggested Lactobacillus rhamnosus GG can inhibit colonization by streptococcal cariogenic pathogens, and therefore reduce tooth decay incidence in children. A study reported a reduced tooth decay incidence in children taking probiotic L. rhamnosus GG-enriched milk versus a control group of children taking milk without probiotic enrichment. Another study showed that bovine milk fermented with Lactobacillus reuteri was effective against S. mutans, resulting in a reduced risk for tooth decay. Also, in a comparative study of S.mutans reduction effects by probiotic administration, showed a reduced S. mutans level in patients receiving probiotics. In another study probiotics effects were assessed after administration; a reduced S. mutans level versus control group was found. Effects of an ice-cream containing Bifidobacterium lactis on S. mutans and Lactobacillus level in saliva were assessed; a significantly reduced level was observed for S. mutans, but not for Lactobacillus. Effects of lactic strains used as probiotics in oral cavity were evaluated; Streptococcus thermophilus and Lactococcus lactis strains were shown to reduce cariogenic bacteria levels (particularly Streptococcus sobrinus and also Streptococcus oralis, Actinomyces naeslundii, and Veillonella dispar).

The effect of probiotics on gingivitis and different grades of periodontitis was studied; probiotics treatment resulted in better microbiota normalization than control group. Researchers showed a significantly reduced gingival index and bacterial plaque amount in patients treated with L. reuteri than in a placebo group and concluded that this probiotic was effective to reduce gingivitis and bacterial plaque deposition in patients with moderate-to-severe gingivitis. High levels of Lactobacillus in microbiota caused an 82% and 65% inhibition in Porphyromonas gingivalis and Prevotella intermedia growth, respectively. Researchers used L. reuteri-containing probiotics in 42 healthy patients and assessed its effects on crevicular fluid volume, cytokine (interleukin-1β, interleukin-6, interleukin-10, and TNF-α) levels, and bleeding on probing. Crevicular fluid volume, as well as TNF-α and interleukin-8 levels, and bleeding were significantly reduced.

A study showed that three types of bacteria were commonly associated with fresh breath. Six other types of bacteria were also found in people with bad breath. Regular use of probiotics can help to control bad breath. After taking Weissella cibaria, reduced levels of volatile sulfide components produced by Fusobacterium nucleatum were observed; the effect could be due to hydrogen peroxide production by W. cibaria, causing F. nucleatum inhibition. Streptococcus salivarius also suppress volatile sulfide effects, by competing for colonization areas with volatile sulfide-producing species.

How is Oralzym-F different from a digestive probiotic?

All probiotics are not the same. Oralzym-F is one of the best clinically shown probiotics specifically created for oral health. Oralzym-F contains a unique blend of 17 strains of beneficial oral probiotics including Lactobacillus reuteri, S. salivarius (BLIS K12 and BLIS M18 ), ‏Streptococcus thermophilus, Bacillus coagulans and Lactococcus lactis designed to restore the balance and strengthen the defense mechanisms of the mouth. Oralzym-F is a professional grade oral probiotic that contains the MOST POWERFUL beneficial probiotic blend ON THE PLANET. Oralzym-F is the latest in major advancements for the care of your oral health. Oralzym-F is absolutely the world’s best and the one and only probiotic product for complete oral care.

A healthy body starts with a healthy mouth. And a healthy mouth starts with Oralzym-F 

Oralzym-F is a probiotic concentrate used as a mouth rinse to reduce plaque buildup, gum irritation and bad breath. Oralzym-F is made for rebalancing of oral bacterial flora. It represents a whole new level of oral care, one in which good oral health is supported and maintained with good microflora –just the way nature intended. Oralzym-F is the first microflora rinse specifically designed for complete oral care. This all-in-one product supports gum and tooth health and naturally freshen breath while gently whitening teeth.

Oralzym-F activates and attachs themselves to the teeth and gum tissue, establishing colonies of live, active beneficial microflora both on the surface of the teeth and deep beneath the gum line. These colonies compete for both nutrients and space with the harmful oral bacteria that disrupt gum and tooth health, as well as cause bad breath. With daily replenishment, the powerful 17 strains of beneficial probiotics used in Oralzym-F helps to reestablish the natural microbial balance in the mouth for healthy gums and teeth, fresher breath and whiter teeth.

Oralzym-F is the most powerful probiotic on the market and is an effective way to readily aid complete oral health.

Oralzym-F can be used just like mouth rinse.

Put 1-3 drops of Oralzym-F into your mouth using the dropper and then rinse mouth with water for at least 30 seconds and spit. You may also gargle with the diluted Oralzym-F for a healthier tongue, throat, and to stop and cure bad breath. It’s Fast-Acting. You can actually Feel Sensational Results within a Few Seconds. Don’t drink any water after you do this step. This should be the last step before you go to bed.  For best results, use Oralzym-F after brushing teeth with Oralzym. Do not eat or drink for 5 minutes.

Oralzym-F delivers results below the gum line and gets to the root of oral care needs.

Many dental care products are antibacterial or antiseptic. This shotgun approach kills oral bacteria indiscriminately and disrupts the bacterial balance in the mouth. While this approach may provide short-term superficial results, it can ultimately increase the imbalance of opportunistic bacteria. For example, antibacterial mouthwashes that claim to wipe out 99.9% of bacteria fail to mention that the bacteria repopulate in about an hour, often leaving the upper hand to the harmful bacteria.

Within one to two hours after using antibacterial mouthwash or breath freshener, the surviving 1% of the bacteria remaining in the mouth can repopulate the full level of harmful bacteria that was present in the mouth before the product was used. This indiscriminate destruction of bacteria creates ongoing imbalances in the microflora that naturally inhabits the oral cavity. The powerful microflora in the mouth are natural antagonists to the odor creating bacteria, quickly colonizing to create a healthy balance of microflora and resulting in longer lasting, truly fresher breath.

On the other hand, the blend of beneficial oral microflora created in Oralzym-F crowd out the harmful bacteria by colonizing in the same places bad bacteria like to hide and by competing for the same nutrients.

Daily use of oralzym-F is the fastest, easiest and most effective way to naturally promote oral health and economically replace mouthwashes and breath fresheners.

Within 4-5 days of using Oralzym-F three times daily, the natural healthy oral balance of good microflora will be greatly restored and you will begin to notice healthier gums, brighter smile and long-lasting fresh breath.

Oralzy-F contains: 100% natural plant based enzymes, Peppermint, Specialized 17 different strains of oral probiotics.

Warning: Stop “Listerine-ning” your Mouth….Top Mouthwash Brands linked to Oral Cancer!

http://www.dailytelegraph.com.au/news/sydney-nsw/mouthwash-linked-to-cancer/story-e6freuzi-1111118530255

You no longer have to put harmful chemicals, toothpastes and irritants into your mouth (most of which can make your gums even worse). Oralzym-F does not contain fluoride, chemicals, artificial colors, preservatives, additives, artificial flavors, alcohols, and animal by-products.

Keep out of reach of children. Avoid direct contact with eyes. Store in a cool, dry place.

Natural Red Palm Oil (high in saturated fat) kills Cancer Cells

The Mediterranean dietary pattern has a well-established beneficial role in preventative for both heart disease and some cancers. Despite its name, this diet is not typical of all Mediterranean cuisine. In Northern Italy, for instance, lard and butter are commonly used in cooking, and olive oil is reserved for dressing salads and cooked vegetables. Butter, especially grass fed butter, contains significant levels of palmitic acid. Unfortunately, butter also contains a lot of oleic acid (the fatty acid also abundant in olive oil). This ratio is not acceptable on cancer cure diet. Palm oil contains about 50% saturated and 50% unsaturated fatty acids (39% monounsaturated and 11% polyunsaturated fatty acids). Olive oil contains predominately monounsaturated fats. We are not trying to exclude polyunsaturated fats on cancer cure diet.

In addition, red palm oil is one of the richest plant sources of cancer fighting squalene and heart protective CoQ10. It is the richest food source of the two most important antioxidant nutrients–vitamin E and beta-carotene. Unrefined palm olein (which is bright red in color) is a major source of carotenoids which inhibit some types of cancer. The unrefined oil is also a rich source of phytonutrients such as beta-carotene, alpha-carotene, vitamin-E, lycopene and other carotenoids. These carotenoids are responsible for the striking red color of the oil. It is the premier source of tocotrienol, a highly potent form of vitamin E that is gaining recognition as a powerful anticancer, heart protective antioxidant. Red palm oil is the only vegetable oil that has abundant tocotrienol content.

Tropical oils: nutritional and scientific issues.

Red palm oil: nutritional, physiological and therapeutic roles in improving human wellbeing and quality of life.

Red palm oil has been used for thousands of years as cooking oil in the East, but has only recently become available in the West. At the moment, red palm oil is available at selected health shops. We are aware of the fact that important nutrients can be broken down or destroyed when food is cooked / processed. Red palm oil is known to be healthier than refined (discolored) palm oil. This is a result of several mitigating substances found in the red palm oil. These compounds are:

• Beta-carotenes (present in higher amounts than in regular oil)
• Co-enzyme Q10 (ubiquinol)
• Squalene
• Vitamin A
• Tocotrienol (Vitamin E)

Refining these oils makes them unhealthy for us. Palm oil products are made using milling and refining processes. By melting and degumming, impurities can be removed and then the oil filtered and bleached. Next, physical refining removes smells and coloration, to produce refined bleached deodorized palm oil (RBDPO), and free sheer fatty acids, used as an important raw material in the manufacture of soaps, washing powder and other hygiene and personal care products. RBDPO is the basic oil product which can be sold on the world’s commodity markets, although many companies fractionate it out further into palm olein, for cooking oil, or other products.

Organic virgin red palm oil is processed up to 10 times faster than standard palm fruit oil to ensure the preservation of the oils natural goodness and quality. Expeller pressing, the chosen method of extraction used to protect the freshness and quality of edible oils, is used to extract the oil from the palm. However, palm oil, especially organic virgin red palm oil that gets all the attention for its positive health effects, has a strong and unusual flavor, but it’s one many people seems dislike, probably it’s so unfamiliar to our plates. Moreover, it has a rather strong bitter taste that we weren’t expecting, but is fine for cooking.

Herbalzym’s  Fermented Organic Virgin Red Palm Oil

The fermentation is one of the few methods of preservation which actually enhances the nutritional value of a food. This can make the nutrients within the food more bioavailable. To create the highest level of concentrated nutrients, Herbalzm’s organic virgin red palm oil (Red-PalmZym) is fermented naturally. Fermentation is a natural method of concentrating raw food materials, and preserving them. But we use no ordinary fermentation process. The method we have developed processes the red palm oil through a proprietary non-heating natural enzymatic fermentation. The process can take up to three weeks and is carefully handled throughout the process to ensure the oil is clean and natural.

Fermentation adds new nutrients, and makes the entire symphony of ingredients easy to digest, and more quickly absorbed by your body. Our “unique” fermentation process retains and amplifies the positive health effects of organic virgin red palm oil. Fermented red palm oil (Red-PalmZym) smells marvelous, and tastes great; it is mild and pleasant and is added to salad dressings, to smoothies, used to saute vegetables. It is also wonderful spread on warm crusty bread. Of course, you can also take 1 Tablespoon (15 ml) of  Red-PalmZym 2-3 times every day. One Tablespoon of red palm oil provides the equivalent of the adult RDA of vitamin E and Vitamin A (as provitamin A carotenes). We have never found any contaminants in our naturally produced Red-PalmZym. Benefits of fermented red palm oil (Red-PalmZym) are many and varied. Many patients notice improvements within the first month; however, it usually takes about two months to notice more dramatic results.

A small amount of estrogen (female sex hormone) is necessary in men to prevent bone loss and for sex drive. Progesterone is produced in small amounts in men too. Progesterone has its reputation as a female hormone due to its role in promoting pregnancy. But natural progesterone is as vital for men’s health as it is for women’s.; this however has not yet been made totally clear. When it comes to men and progesterone, progesterone protects men against excessive estrogen. Like women, men are also at risk of becoming estrogen dominant, and the symptoms, although different from women’s, can also be dire.

As men age, progesterone levels fall, testosterone becomes converted to dihydrotestosterone (DHT) and estrogen levels rise and become dominant. A healthy male has approximately 1000 to 1200 nanograms/dl of testosterone at the age of 20. After the age of 35 there is a steady decline in these levels. By the age to 40 to 50 one sees a significant drop in these levels. By the age of 80 these levels decline to pre-puberty levels of 100 to 200 nanograms/dl. The effect of this is weight gain, some breast enlargement, an enlarged prostate gland and sometimes prostate cancer. DHT acts on the skin, sometimes producing acne, and on the hair follicles, putting hair on the chest but often taking it off the scalp. Male-pattern baldness (androgenic alopecia) is one thing, prostate disease quite another. The conversion of testosterone to DHT is promoted by the enzyme 5-alpha-reductase. This is important since testosterone antagonizes and limits estrogen effects, thus preventing prostate cancer.

Diet, Obesity, and Prostate Health: Are We Missing the Link?

Hormones and prostate carcinogenesis: Androgens and estrogens.

Aromatase and regulating the estrogen:androgen ratio in the prostate gland.

The dual, opposing roles of estrogen in the prostate.

5alpha-reductase isozymes and androgen actions in the prostate.

Androgen regulation of 5α-reductase isoenzymes in prostate cancer: implications for prostate cancer prevention.

Aromatic esters of progesterone as 5alpha-reductase and prostate growth inhibitors.

We know that too much estrogen and progesterone will lead to loss of muscle mass, gains in fat and loss of libido. At the right levels, but more importantly the ratio/proper balance of these hormones could actually be beneficial for libido, prostate health, cardiovascular health and body composition. However, we are continuously surrounded by environmental pollutants that have estrogen-like activity called Xenoestrogens, which are primarily petrochemical origin. Our diet is also contaminated with hormones. Synthetic estrogens are now used to fatten cattle, as well as other meat-producing animals, and to increase milk and egg production. Synthetic hormones have molecular structures that are not compatible with our physiology. We do not have enzymes designed to modify their effects, nor can they be efficiently excreted. Therefore, these synthetics can have an unnatural and far more potent hormonal effect on our body systems than natural hormones. Today millions of men young and old suffer from disorders related to hormone imbalance due to the high levels of estrogen in our diet and the environment. This has affected approximately 50% men above the age of 40 years and 80% above the age of 70 years. In short, hormone imbalance has reached epidemic proportions.

Environmental signaling: what embryos and evolution teach us about endocrine disrupting chemicals.

Endocrine dismodulation and cancer.

Hormones impact your body at the cellular level. Your overall health depends to a large degree on your body’s ability to maintain healthy cells. Dietary changes and deep breathing exercise influence your hormones and your body’s ability to balance them naturally. This applies to both men and women of all ages. The elements of natural prostate cancer therapy are include: dietary changes, possible hormonal balancing, vitamin D and mineral supplements, oral herbalzym supplements, deep breathing exercise program, fresh air and some sunlight exposure, stress management training if necessary, detoxification, and immune enhancing herbalzym-diet.

The equilibrium of sexual hormones in both sexes is controlled in vertebrates by the enzyme aromatase which catalyzes the conversion of androstenedione and testosterone into estrone and estradiol, respectively. Chrysin is a flavonoid derived from the blue passion flower (Passiflora coerulea). Small amounts are also found in honey and in propolis. The ability of chrysin to inhibit aromatase and estrogen production has been repeated in various studies over the years, and pharmaceutical companies are also interested in the cancer-fighting abilities of this natural substance. A recent study further supports the value of chrysin as an anti-cancer agent. Chrysin also has antioxidant properties and is an effective anti-inflammatory agent. Some bodybuilders say they take chrysin because it reportedly boosts testosterone levels, but no studies have verified this claim.

There are a number of supplement companies that sell chrysin pills. Unfortunately it is recognized that the therapeutic effectiveness of chrysin is limited due to its low solubility and poor absorption from the GI tract, which means that most of what you swallow goes directly into gastrointestinal area and is expelled. Very little remain in the bloodstream about an hour or so after ingestion. So the use of the natural fermentation to enhance its uptake is particularly beneficial. ProstaZym contains enzymatic fermented chrysin. It has perfect bioavailability and pharmacokinetics of active chrysin. ProstaZym greatly improve the cellular uptake of chrysin, with clinically validated efficacy in prostate cancer treatment.

Flavonoid inhibition of aromatase enzyme activity in human preadipocytes.

Effects of chrysin on urinary testosterone levels in human males.

Chrysin, a natural flavonoid enhances steroidogenesis and steroidogenic acute regulatory protein gene expression in mouse Leydig cells.

Chrysin sensitizes tumor necrosis factor-alpha-induced apoptosis in human tumor cells via suppression of nuclear factor-kappaB.

Chrysin inhibits expression of hypoxia-inducible factor-1alpha through reducing hypoxia-inducible factor-1alpha stability and inhibiting its protein synthesis.

Since palm kernel oil and coconut oil have very high contents of lauric acid, they are referred to as lauric oils. Lauric acids block the conversion of testosterone to 5alpha-dihydrotestosterone (DHT) and then inhibit the proliferation of prostate cancer cells.

Anti-androgenic activity of fatty acids.

There are three main types:

• Low-density lipoprotein (LDL): this carries cholesterol from the liver to the cells and, if supply exceeds demand, can cause harmful build-up of cholesterol
• High-density lipoprotein (HDL): this takes cholesterol away from the cells and back to the liver, where it’s either broken down or excreted
• Triglycerides: fats carried in the blood from the food we eat

Triglycerides and cholesterol are both fatty substances known as lipids. But triglycerides are fats; cholesterol is not. Cholesterol is a waxy, odorless substance made by the liver that is an essential part of cell walls and nerves. Carbohydrate intake increases triglycerides, the form in which the body stores energy for when we need it, not saturated fat intake.

Saturated fats are not as bad as trans-fats. Trans-fats are found in margarine, fast food, deep-fried foods—including French fries and potato chips, baked goods, processed convenience foods, candies, cured and aged foods such as sausages, luncheon meats, and some cheeses. Stay away from these kinds of foods. In spite of its level of saturated fatty acid content (50%), red palm oil has not been found to promote atherosclerosis and/or arterial thrombosis. Studies show that adding red palm oil into the diet can remove plaque buildup in arteries and therefore, reverse the process of atherosclerosis. Removing plaque is not the only way red palm oil protects against strokes and heart attacks. Red palm oil can also improve cholesterol values. This has been demonstrated in both animal and human studies. Red palm oil does not raise health concerns typically associated with saturated fats

Red palm oil: nutritional, physiological and therapeutic roles in improving human wellbeing and quality of life.

Dietary red palm oil supplementation decreases infarct size in cholesterol fed rats.

Saturated fats, however, in meat/dairy products are less desirable. They are not medium chain triglycerides. We also have to consider the monumental and disastrous effects of feeding ruminants corn and how that has impacted the fat they carry and the impact on those of us who eat beef. Grass-fed beef doesn’t have the sort of dangerous fat that corn-fed does. Saturated fats mostly come from animal sources and at room temperature are solid. Unsaturated fats are liquid at room temperature. Saturated fatty acids (SFAs) are referred to as saturated because all available carbon bonds are tied up with a hydrogen atom. That is, there are no openings for rancidity or spoilage, whereas a polyunsaturated fatty acid containing two or more pairs of double bonds without hydrogen atoms occupying the open space is wide open for oxidation. SFAs are shelf-stable, resistant to heat damage, and essential to many bodily functions. SFAs, such as palmitate, have long been shown to induce toxicity and cell death in various types of cells.

There appears to be a positive correlation between the quantity and quality of fat consumed and incidence of cancers such as breast cancer, colon cancer and prostate cancer. For example, polyunsaturated fatty acids, especially those rich in omega-6 fatty acids derived from vegetable seed oils, have tumor promoting effects. Saturated fats such as palmitic acid (meat, butter, palm oil) and lauric acid (coconut oil, palm kernel oil) and unsaturated fats such as oleic acid (olive oil) and DHA (fish oil) play opposing roles in immune activation. Saturated fats activate the immune system while unsaturated fats inhibit it. It is possible that the ingestion of saturated fats such as palm oil, palm kernel oil or coconut oil could activate immune responses against cancer, to a more appropriate cell mediated immune responses. Unsaturated fatty acids would block this important cell mediated immune responses. Omega-6 fatty acids indeed fuel cancer growth.

Roughly half of our cell membrane structure is composed of saturated fats. The membrane lipid ceramide is the backbone of all complex sphingolipids and acts as a second messenger in many biological events (ceramide is stored in an inactive form as a sphingolipid). In addition, ceramide regulates several biochemical and genetic events. Ceramide is a product of palmitic acid and the amino acid serine. Palmitic acid is a well known cytotoxic agent against cancer cells. Ceramide is involved in the induction of apoptosis (programmed cell death). Considering the central role of ceramide in mediating physiological as well as pharmacologically stimulated apoptosis, ceramide can be considered a tumor-suppressor lipid. In contrast, sphingosine-1-phosphate, which is generated from ceramide by the consecutive actions of ceramidase and sphingosine kinase, can be considered a tumor-promoting lipid, and the enzyme responsible for its synthesis functions as an oncogene.

Saturated fatty acid metabolism is key link between cell division, cancer, and senescence in cellular and whole organism aging.

Synergistic effect of cAMP and palmitate in promoting altered mitochondrial function and cell death in HepG2 cells.

Ceramide synthases at the centre of sphingolipid metabolism and biology.

An overview of sphingolipid metabolism: from synthesis to breakdown.

Cancer treatment strategies targeting sphingolipid metabolism.

Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance.

Altering the sphingosine-1-phosphate/ceramide balance: a promising approach for tumor therapy.

Palm oil is the beautiful stuff. Palm oil, particularly virgin or red palm oil, is a traditional fat that has been a part of the human diet for over 5000 years. For generations red palm oil has been revered as both a nutritious food and a valuable medicine. Palm oil and palm kernel oil have different chemical and physical properties, different nutritional and metabolic properties, and come from different parts of the oil palm. The main fatty acids of palm oil are palmitic, oleic, linoleic and stearic. Palmitic acid accounts for 44% of the total fatty acid composition of palm oil. In no other commerical vegetable oil does palmitic acid accumulate to this extent. In the oil palm, the pertinent question to be answered is why palmitic acid accumulates in the mesocarp.

In contrast the main fatty acids of palm kernel oil are lauric, myristic, oleic and palmitic. Note that amongst these fatty acids, lauric, myristic, palmitic and stearic are saturated fatty acids (12, 14, 16 and 18 carbons, respectively). Palm oil is also at times confused with coconut oil. Actually, coconut oil has a fatty acid profile that is almost identical to that of palm kernel oil. Since palm kernel oil and coconut oil have very high contents of lauric acid, they are referred to as lauric oils. Lauric acids block the conversion of testosterone to 5alpha-dihydrotestosterone (DHT) and then inhibit the proliferation of prostate cancer cells. Oleic acid is monunsaturated (18 carbons, 1 double bond) while linoleic acid is polyunsaturated (18 carbons, 2 double bonds).

Sitosterol, campesterol, stigmasterol and cholesterol largely constitute the phytosterols in palm oil. Some of the minor components in palm oil include the carotenoids, tocopherols, tocotrienols, sterols, phosphatides, triterpenic and aliphatic alcohols. Of these, the carotenoids and tocotrienols are of interest. Red palm oil is one of the richest natural sources of carotenoids (beta-carotene and alpha-carotene). It has 15 times more provitamin A carotenes than carrots and 300 times more than tomatoes. Red palm oil gets its name from its characteristic dark red color. The color comes from carotenes such as beta-carotene and lycopene—the same nutrients that give tomatoes and carrots and other fruits and vegetables their rich red and orange colors. Beta carotene, a precursor of vitamin A, is the most widely studied carotenoid. Beta carotene has long been postulated to be beneficial as an anticancer agent.

Carotenoid intakes and risk of breast cancer defined by estrogen receptor and progesterone receptor status: a pooled analysis of 18 prospective cohort studies.

The effect of dietary carotenoids on lung tumorigenesis induced by intratracheally instillated diesel exhaust particles.

Palm tocotrienols also have powerful anti-cancer properties. Palm tocotrienols inhibit proliferation of cancer cells whereas alpha-tocopherol has no effect. The anti-proliferative effect of palm tocotrienols is attributed to an increase in apoptosis by increased DNA fragmentation. Tocotrienol targets multiple cell signaling pathways and deliver multiple punches to treat cancer.

Tocotrienols fight cancer by targeting multiple cell signaling pathways.

Suppression of tumor growth by palm tocotrienols via the attenuation of angiogenesis.

Chemoprevention of tocotrienols: the mechanism of antiproliferative effects.

Induction of cytotoxicity in human lung adenocarcinoma cells by 6-O-carboxypropyl-alpha-tocotrienol, a redox-silent derivative of alpha-tocotrienol.

d-δ-Tocotrienol-mediated suppression of the proliferation of human PANC-1, MIA PaCa-2, and BxPC-3 pancreatic carcinoma cells.

Gamma-tocotrienol suppresses prostate cancer cell proliferation and invasion through multiple-signalling pathways.

Vitamin E and cancer: An insight into the anticancer activities of vitamin E isomers and analogs.

Reduction of DNA damage in older healthy adults by Tri E Tocotrienol supplementation.

Anti-angiogenic activity of tocotrienol.

Induction of apoptosis in human breast cancer cells by tocopherols and tocotrienols.

Effect of tocotrienols on the growth of a human breast cancer cell line in culture.

Long-term administration of tocotrienols and tumor-marker enzyme activities during hepatocarcinogenesis in rats.

Red palm oil can be used as a dietary supplement to provide a natural source of mixed vitamin E, mixed carotenoids, vitamin K, CoQ10, squalene, phytosterols, and other nutrients. The easiest way to take palm oil for its nutritional value is with foods. Use the oil in food preparation. You can also take the oil by the spoonful. One Tablespoon (15ml) of red palm oil provides the equivalent of the adult RDA of vitamin E and Vitamin A (as provitamin A carotenes). Red palm oil is non-toxic even in large amounts. It is a food, so it doesn’t have any harmful side effects often associated with drugs. You could safely eat several tablespoons. The only potential drawback you might experience if you consume large amounts of red palm oil every single day is a slight yellowing of the skin. This is caused by the accumulation of carotenes in the skin.

In order to properly achieve weight loss you ought to maintain disciplined weight loss objectives and keep a sustained degree of determination and persistence to make sure you stand a great chance. Despite the fact that it depends on your initial weight, an idea of a reasonable objective could be to reduce 2 lbs (about 900g) weekly. Otherwise, you might want to establish longer term objectives, for example dropping 20% of your weight or, how about, 30 lbs (about 14 kg) during the following 3 months. Through establishing objectives and retaining a self-disciplined strategy to weight loss, it is possible to attain your required weight loss.

However, there is no way to lose weight without feeling some degree of hunger. Hunger control is obviously the key to successful weight loss. There are many strategies that help reduce hunger: avoiding refined carbohydrates, getting plenty of natural sunlight on your skin, drinking large amounts of water on a regular basis, and getting plenty of fiber in your diet. But there is nothing that absolutely eliminates hunger. Your body’s natural response to calorie deprivation is to increase hunger.

We overeat for lots of reasons, not just because we’re hungry. It is far more complicated than that. A lot of it has to do with hormones secreted by fat cells (leptin) and by stomach and gastrointestinal (GI) tract (Ghrelin, CCK, Neuropeptide YY and others). These hormones interact with central nervous system (brain/hypothalamus) in a way you could describe as turning up the appetite dial a notch. Many of the peptides that are involved in the regulation of food intake in the brain are also found in the enteric nervous system and enteroendocrine cells of the mucosa of the GI tract. Calories go down, appetite goes up, and you go looking for food. When people are under stress, they binge on carbs, especially sugar. Remember that carbs are a tranquilizer.

Neuroendocrine control of food intake.

The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis.

Appetite signaling: from gut peptides and enteric nerves to brain.

Gut peptides and the regulation of appetite.

Brain-gut axis and its role in the control of food intake.

People who have tried, but not had success with a number of slimming pills may want to listen up – there’s a new “miracle weight loss solution” and “perfect hunger control solution”. Now imagine if losing weight was this simple and relaxing as well. By fueling your body with the right natural foods and treating your body to comfortable and calming beauty treatments, YogurtZym Diet.

YogurtZym provides the perfect solution for anyone who has trouble controlling Hunger and Carbohydrate Addiction. It turns off your hunger like a light switch. It is easy, simple, natural ways to curb cravings without adding calories. Perfect late at night or for between-meal cravings no matter what diet plan you’re on. When you just feel like eating without having an empty stomach, take 10, 20 or 30 ml of YogurtZym. This is no ordinary yogurt! You’ll probably notice lots of different sensation in your mouth, stomach and gastrointestinal area. So, relax, take a deep breath, and pay attention to everything.

Here are a few methods for teaching yourself to breathe deeply.

• Good breathing posture can help you breathe more efficiently and identify the muscles you engage when inhaling and exhaling (Lie on your back on the floor, and take a deep breath. Feel it growing your lungs. In this placement, you can completely fill your lungs with air. Check out your stomach rise as you inhale completely)
• Beginners sit in a chair with feet flat on the floor or in the lotus position with hands placed on the knees with the palms facing upward, the thumb and index finger together. (Advanced beginners stand up straight with your shoulders back and your pelvis tilted marginally forward. Keep your shoulders, hips, and feet in line with your knees very slightly bent.)
• Bring up your head, but not into an unnatural position. Close your eyes and focus your mind’s eye on your belly button area.
• Breathe through the nose. Do not stop at the top or bottom of your breath. Quiet breathing is especially important.
• Slowly inhale through your nose (8 seconds), drawing the breath toward the abdomen, expanding it, and filling up your belly. Check out your stomach rise as you inhale completely.
• Gently exhale through your nose (8 seconds). Exhale all stale air from lungs, contracting abdominal muscles to squeeze out the last remnants.
• Do this for 20 cycles, and build up to 10 minutes at a sitting.
• Breath in and out several times with precision and attention to detail, then you may arrive at the slight lightness of head – this coming from the oxygen increase

As well as the mental and spiritual benefits, complete breath increases oxygen supply to the blood, bring vitality to all the organs. Complete breath also slows the heart rate. It has a calming effect on central nervous system. The key is to be thorough when you inhale and exhale. Don’t take low depth breaths or release them too fast. You can significantly increase your breath control with this practice method. As you expand your lung capacity, you will have a chance to work at 10 and even 12 second intervals. Notice how powerful this breath feels compared to the breaths you take when you’re leaning over. Feel full… eat well… be slim… be healthy.

What is in YogurtZym?

YogurtZym is an ancient wonder food, strongly antibacterial, antiviral and anticancer. Probiotics are live microorganisms that when administered in adequate amounts confer a health benefit on the host. YogurtZym is probiotic-rich fermented liquid yogurt formula. It is a professional grade probiotics that contains the MOST POWERFUL beneficial microflora blend ON THE PLANET. It is a revolutionary new application of microflora, which have traditionally been used to support digestive and immune health. YogurtZym contains wild-harvested edible mushroom extracts, plant enzymes, herb and vegetable seeds, yucca schidiggera extract, unpasteurized organic wildflower honey, etc.

To create the highest level of concentrated nutrients, YogurtZym is fermented naturally. Fermentation is a natural method of concentrating raw food materials, and preserving them. But YogurtZym uses no ordinary fermentation process. Mushrooms have tough cell walls, which lock health benefits away in indigestible chitin. Fermentation process makes these molecules more available and can help neutralize smaller levels of toxins. Mushrooms really shouldn’t be eaten raw. Fermentation adds new nutrients, and makes the entire symphony of ingredients easy to digest, and more quickly absorbed by your body. Our “unique” fermentation process retains and amplifies the probiotic power of YogurtZym.

A common misconception about mushrooms is that they are of no nutritional value. However, mushrooms are not only delicious and so versatile, but they are crazy-loaded with nutrition and powerful healing properties. They contain numerous substances including glycoproteins, glyconutrients, etc. Mushrooms are rich in disease-fighting phytochemicals. They are also rich in most vitamins, particularly B and C, and contain practically all the major minerals, particularly potassium, magnesium, phosphorus, iron, copper, zinc, chromium and selenium. They supply hard-to-get nutrients.

Mushrooms are low in calories, carbohydrates, fat and sodium. They are very high in water content and fiber which makes them a great diet food. YogurtZym is made from 4 species of wild-harvested edible mushrooms and plant enzymes. These mushrooms have been specifically selected by species and geographical growth area to complement each other in supporting the cell’s metabolism, cell function, immune system, and endurance. This is a powerfully protective tonic and excellent for weight loss.

Here are synergistic superior 4 blends;

• Shitake (Lentinus edodes); Beta-glucans (including Lentinan and the Alpha-glucan KS-2)
• Porcini(Boletus edulis); Beta-glucans, Lectin, Polysaccharides
• Oyster (Pleurotus ostreatus); Lectin, Beta-glucans (Pleuran), Statins (lovastatins)
• Agaricus (Agaricus blazei Murill); Lectin, Agaritine, Beta-glucans (1-3, 1-4, 1-6, D-Beta glucan)

Many species of wild edible mushrooms with medicinal value are widely used for a broad range of diseases. Some species are regarded as therapeutic food for their anti-carcinogenic, anti-cholesteroremic and anti-viral properties. The oyster mushroom contains statins such as lovastatin which work to reduce cholesterol. Most of them possess polysaccharides (complex sugar molecules) called beta-glucans that increase RNA and DNA in bone marrow where immune cells are made. Beta-glucans and other polysaccharides specifically activate the immune system’s cells (such as macrophages, interferon, T cells, and natural killer cells). Beta-glucans are also used to fight high cholesterol by lowering the LDL cholesterol (also known as “bad” cholesterol) levels and raising the HDL cholesterol (also known as “good” cholesterol) levels. They have even been shown to help with diabetes, cancer, allergies, hepatitis, asthma and more. Beta-glucans are also found in yeast, oat bran and other plants

You can literally turn your metabolism into your fat burning slave by ensuring you always have an internal environment primed for burning fat and you do it with your favourite foods. YogurtZym creates the perfect environment in your body that allows you to burn fat fast, and delivers what your body is hungry for:

• A real aid in achieving your weight loss goals
• A perfect hunger control (overcoming carbohydrate addiction)
• A metabolism support (bringing blood glucose, blood pressure levels back to normal)
• A fat flush (lowering bad cholesterol level)
• A regular and healthy bowel
• A renovation in the clarity, texture, and tone of your skin
• A new energy — the energy you’ve been missing for years
• A boost in the strength of your body’s immunity (antibacterial, antiviral and anticancer activities)
• A supporting gum and tooth health while freshening breath

YogurtZym is the world’s best probiotics for complete oral care

Research has shown that not only are probiotics beneficial for digestive and immune health, they can also affect your oral health. YogurtZym is a professional-strength oral-care probiotic, which, when used twice daily, can help support gum and tooth health, freshen breath and naturally and gently whiten teeth. YogurtZym probiotics are blended to address the oral care needs and even your pets can have fresher breath and whiter, cleaner teeth with YogurtZym.

Wild and commercial mushrooms as source of nutrients and nutraceuticals.

Edible mushrooms: role in the prevention of cardiovascular diseases.

Functional properties of edible mushrooms.

Lack of energy compensation over 4 days when white button mushrooms are substituted for beef.

Dietary Shiitake Mushroom (Lentinus edodes) Prevents Fat Deposition and Lowers Triglyceride in Rats Fed a High-Fat Diet.

Pleurotus fruiting bodies contain the inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase-lovastatin.

Fermented mushroom milk-supplemented dietary fibre prevents the onset of obesity and hypertriglyceridaemia in Otsuka Long-Evans Tokushima fatty rats.

Chemical analysis and antioxidant activity in vitro of polysaccharides extracted from Boletus edulis.

Immunological effects of yeast- and mushroom-derived beta-glucans.

Cholesterol-lowering effects of oat β-glucan.

Concentrated oat beta-glucan, a fermentable fiber, lowers serum cholesterol in hypercholesterolemic adults in a randomized controlled trial.

What are some other health benefits of YogurtZym?

Using YogurtZym daily as a supplement to your healthy diet can improve the following conditions:

• Diabetes
• Hypoglycemia
• High Cholesterol
• High blood pressure
• Cancer and Leukemia
• Chronic infections
• Eczema
• Nervousness
• Stress
• Carpal tunnel
• Anemia
• Fatigue
• Constipation
• Sexual dysfunction in men (ED) and women
• Repels fleas when given to household pets

The nutrient in the YogurtZym that helps with diabetes is chromium. Chromium is also the part of YogurtZym that helps lower LDL (bad) cholesterol and raise HDL (good) cholesterol. The chromium in YogurtZym is more bio-available, allowing the body to use it more effectively than the type found in supplements.

In addition, it’s important to get blood sugar under control to help restore insulin sensitivity through the right nutrition. This means greatly reducing sugars and refined starches in your diet (including fully eliminating any use of harmful high fructose corn syrup), and focusing more of your diet on healthy fats (such as coconut fat, fatty fish and fish oils, avocados, nuts, seeds, olive oil, free-range eggs, etc), as well as increasing protein and fiber intake. The best weight loss tips is following a diet plan without costing your health, without feeling hungry and most importantly without getting the extra weight back once you stop the diet. The way to do this is to increase the pace of your metabolism. And the best way to succeed is to get into the habit of deep breathing exercise. Deep breathing exercise routines are also very effective at increasing your fat-burning hormones and creating a hormonal environment conducive to burning off abdominal fat, including visceral fat. Deep breathing is an essential part of maximizing any form of exercise you do.

Steps required for making YogurtZym at Home

1. Sterilize jar and lid in the Microwave (10 secs)
2. Mix 3/4 cup organic low-fat milk with 1/4 cup of YogurtZym
3. Pour the mixture into jar
4. Cover immediately. Do not tighten lid.
5. Leave at room temperature for 10-12 hours
6. Stir well and Drink 10, 20, or 30 ml (1 fl oz) whenever you feel hungry throughout the day
7. Keep the rest in the refrigerator

In addition, the following video demonstrating the 13-step Tai Chi warm-up exercises . These simple steps are suitable for both the young and elderly. You will feel good after doing just a few cycles – the more cycles you do, the more Qi (energy) you will get from these very easy stretching exercises. Let’s Keep Fit & Healthy!

YogurtZym 500 ml (16.9 fl oz) will soon be up for sale on eBay

Several species of mushrooms have been used as adaptogens (also known as biological response modifiers), or general tonics, to promote overall wellness and vitality. There are many botanicals that act as adaptogens to assist the body in adapting to environmental and psychological stress. Adaptogens, including medicinal mushrooms, benefit all of the important systems of the body, including the nervous, endocrine, adrenal, and immune systems, by increasing or decreasing their function, as needed, for maximum health. A common misconception about mushrooms is that they are of no nutritional value. However, mushrooms are not only delicious and so versatile, but they are loaded with nutrition and powerful healing properties. They contain numerous substances including glycoproteins, glyconutrients, etc. Mushrooms are rich in disease-fighting phytochemicals. They are also rich in most vitamins, particularly B and C, and contain practically all the major minerals, particularly potassium, magnesium, phosphorus, iron, copper, zinc, chromium and selenium. They supply hard-to-get nutrients.

All wild edible mushrooms contain medicinal qualities too, as most of them possess polysaccharides (beta glucans). Beta-glucans and other polysaccharides specifically activate the immune system’s cells (such as macrophages, interferon, T cells, and natural killer cells) in order to prevent the multiplication, metastasis, and recurrence of cancer cells. Another function of beta-glucans is to attach to the receptor sites on the immune cells and to activate them, allowing them to recognize the cancer cells as “foreign invaders” and creating a higher state of  immune response. Laboratory experiments have confirmed that several substances in wild edible mushrooms, in addition to the beta-glucans and other polysaccharides, have anti-tumor effects. These include nucleic acids, lectins, sterols, and lipids. The combination of these compounds in mushrooms is believed to enhance the functioning of the immune system. All wild edible mushrooms are probiotic, meaning that they help our body strengthen itself and fight off illness by maintaining physiological homeostasis, restoring our bodies balance and natural resistance to disease.

Immunological effects of yeast- and mushroom-derived beta-glucans.

Functional properties of edible mushrooms.

Chemical analysis and antioxidant activity in vitro of polysaccharides extracted from Boletus edulis.

Oral ingestion of Lentinula edodes mycelia extract can restore the antitumor T cell response of mice inoculated with colon-26 cells into the subserosal space of the cecum.

Characterization and immunomodulating activities of polysaccharide from Lentinus edodes.

Effect of polysaccharide from cultured Cordyceps sinensis on immune function and anti-oxidation activity of mice exposed to 60Co.

Immunostimulating activity of the polysaccharides isolated from Cordyceps militaris.

The Mushroom Agaricus blazei Murill Elicits Medicinal Effects on Tumor, Infection, Allergy, and Inflammation through Its Modulation of Innate Immunity and Amelioration of Th1/Th2 Imbalance and Inflammation.

Potential antitumor activity of a low-molecular-weight protein fraction from Grifola frondosa through enhancement of cytokine production.

Structure of a lectin with antitumoral properties in king bolete (Boletus edulis) mushrooms.

The antineoplastic lectin of the common edible mushroom (Agaricus bisporus) has two binding sites, each specific for a different configuration at a single epimeric hydroxyl.

Anti-inflammatory activity of edible oyster mushroom is mediated through the inhibition of NF-κB and AP-1 signaling.

Immunostimulatory activities of a low molecular weight antitumoral polysaccharide isolated from Agaricus blazei Murill (LMPAB) in Sarcoma 180 ascitic tumor-bearing mice.

Many species of wild edible mushrooms with medicinal value are widely used for a broad range of diseases. Some species are regarded as therapeutic food for their anti-carcinogenic, anti-cholesteroremic and anti-viral properties. Unlike most other complementary or alternative cancer therapies offered in America, the substances in medicinal mushrooms are being used as mainstream therapy in China, Japan and Korea, and have actually been proven (in laboratory, animal, and human studies) to have powerful anti-tumor activity. They have also been shown to significantly enhance the body’s own immune system to eliminate, or stop the spread, of many cancerous tumors. These so called biological response modifiers can be potent antiviral and antitumor agents, not by killing viruses or cancer cells directly but by stimulating the body’s innate ability to marshal cellular defenses. In a recent clinical trial, immune-assist has been shown to significantly reduce the adverse effects of radiation and chemotherapy, including loss of appetite, energy, and hair, as well as reducing the incidence of nausea.

The reality is that this fascination for the medicinal value of wild edible mushrooms is not new. For 3,000 years, the Chinese have looked to mushrooms for their healing powers. The Japanese and Korean have also looked into the healing properties of mushrooms for centuries, so it is fitting that many modern day discoveries regarding the medicinal application of mushrooms have been pioneered by them. In almost all entire laboratory studies published to date, the rate of remission for all types of cancer has been in the high 90% range. While most of these studies have been done with animals, similar results may be shown as clinical studies are conducted on humans. One human study showed that human subjects given wild edible mushrooms in their diet experienced an increase of NK (Natural Killer) cells of 3,000% in 2-4 days.

Oral ingestion of Lentinula edodes mycelia extract inhibits B16 melanoma growth via mitigation of regulatory T cell-mediated immunosuppression.

Anticancer activity of subfractions containing pure compounds of Chaga mushroom (Inonotus obliquus) extract in human cancer cells and in Balbc/c mice bearing Sarcoma-180 cells.

Cancer cell cytotoxicity of extracts and small phenolic compounds from Chaga [Inonotus obliquus (persoon) Pilat].

Natural killer cell activity and quality of life were improved by consumption of a mushroom extract, Agaricus blazei Murill Kyowa, in gynecological cancer patients undergoing chemotherapy.

Agaricus blazei Murill enhances doxorubicin-induced apoptosis in human hepatocellular carcinoma cells by NFκB-mediated increase of intracellular doxorubicin accumulation.

Agaritine from Agaricus blazei Murrill induces apoptosis in the leukemic cell line U937.

Maitake (D fraction) mushroom extract induces apoptosis in breast cancer cells by BAK-1 gene activation.

Characterization and antitumor effect of a novel polysaccharide from Grifola frondosa.

Commonly consumed and specialty dietary mushrooms reduce cellular proliferation in MCF-7 human breast cancer cells.

Pleurotus ostreatus inhibits proliferation of human breast and colon cancer cells through p53-dependent as well as p53-independent pathway.

Inhibitory mechanisms of Agaricus blazei Murill on the growth of prostate cancer in vitro and in vivo.

A low molecular weight polysaccharide isolated from Agaricus blazei suppresses tumor growth and angiogenesis in vivo.

Recent research has indicated that whole mushroom extracts, with concentrations of polysaccharides, are more effective than isolated polysaccharides. Several studies have shown that other components of the mushrooms, besides the polysaccharides, also have anti-cancer and healing properties. The combination of all these elements, as found in whole mushroom extracts, appears to be superior. Hepazym-F is a potent, and very safe, pharmaceutical quality blend of 7 effective mushroom extracts to be used in conjunction with chemotherapy, radiation, or surgery. This formula can also be used by people who have completed conventional cancer treatment, or by people who just want to significantly strengthen their immune systems to aid in warding off illness and disease.

There are over 400 species of wild edible mushrooms. Research proved that all wild edible mushrooms are not equal. The nutritional and therapeutic value of a species of wild edible and medicinal mushrooms varies, depending on the geographical area of growth. Hepazym-F is developed to bring together a mixture of some of the most powerful and research-supported immune modulating mushrooms along with the added benefits of the anticancer, antiviral, antibacterial, antiinflammatory, hepatoprotective, and antioxidant activities. Hepazym-F is made from 7 species of wild-harvested edible mushrooms. These mushrooms have been specifically selected by species and geographical growth area to complement each other in supporting the immune system, cell function and endurance. This is a powerfully protective tonic and excellent for building immune function. Hepazym-F is purified using a specific double-extraction method to concentrate a broad range of medicinal elements. This extraction method keeps the delicate enzymes and other phytonutrients intact. This is the most beneficial extraction method because of its ability to preserve and concentrate all the wonderful things that Hepazym-F has to offer.

To create the highest level of concentrated nutrients, Hepazym-F is fermented naturally. Fermentation is a natural method of concentrating raw food materials, and preserving them. But Hepazym-F uses no ordinary fermentation process. Mushrooms have tough cell walls, which lock health benefits away in indigestible chitin. Fermentation process makes these molecules more available and can help neutralize smaller levels of toxins. Mushrooms really shouldn’t be eaten raw. Fermentation adds new nutrients, and makes the entire symphony of ingredients easy to digest, and more quickly absorbed by your body. Our ”unique” fermentation process retains and amplifies the probiotic power of Hepazym-F. Unlike ordinary food processing, our fermentation system not only improves the overall nutritional value of the phyto-dense formula, it reduces toxins and anti-nutritive by-products. This is the great advantage of its probiotic effect in your body. Hepazym-F creates the perfect environment for your probiotics to thrive, and delivers what your body is hungry for: a regular and healthy bowel, a renovation in the clarity, texture, and tone of your skin, a new energy – the energy you’ve been missing for years, a real aid in achieving your weight loss goals, and a boost in the strength of your body’s anticancer immunity.

Here are synergistic superior 7 blends;

• Shitake (Lentinus edodes); Beta-glucans (including Lentinan and the Alpha-glucan KS-2)
• Chaga (Inonotus obliquus); Beta-glucans , Protein bound polysaccharide (xylogalactoglucose), Triterpenes, Melanin complex, Ergosterols, Betulin and Betulinic acid (concentrated from Birch bark)
• Cordyceps sinensis; Beta-glucans (plus Deoxyadenosine and other nucleosides), Mannitol (Cordicepic acid), Adenosine
• Maitake (Grifola frondosa); Beta-glucans, Protien bound polysaccharide
• Porcini (Boletus edulis); Beta-glucans, Lectin, Polysaccharide (BEPF30, BEPF60 and BEPF80)
• Oyster (Pleurotus ostreatus); Lectin, Beta-glucans (Pleuran), Statins (lovastatins)
• Agaricus (Agaricus blazei Murill); Lectin, Agaritine, Beta-glucans (1-3, 1-4, 1-6, D-Beta glucan)

Extracellular adenosine initiates most of its effects through the activation of adenosine receptors. There are at least four subtypes of the adenosine receptor A1, A2A, A2B and A3 receptors. Adenosine receptors are all coupled to G-proteins and the A1 and A3 subtypes are associated with inhibitory G-proteins. Each of these four cell surface adenosine receptors (ARs) is found to be upregulated in various tumor cells. It is overexpressed in inflammatory and cancer cells, while low expression is found in normal cells. The adenosine receptors are important and ubiquitous mediators of cellular signaling, which play vital roles in protecting tissues and organs from damage. In particular, adenosine triggers tissue protection and repair by different receptor-mediated mechanisms, including an increase of oxygen supply/demand ratio, preconditioning, anti-inflammatory effects, and stimulation of angiogenesis. Activation of the receptors by specific ligands, agonists or antagonists, modulates tumor growth via a range of signaling pathways. At the present time, it can be speculated that adenosine A1, A2A, A2B, and A3 receptor-selective ligands may show utility in the treatment of cancer and other disorders in which inflammation is a feature.

Introduction to adenosine receptors as therapeutic targets.

Adenosine receptors and cancer.

Inhibition of T cell and natural killer cell function by adenosine and its contribution to immune evasion by tumor cells (Review).

Enhancement of tumor immunotherapy by deletion of the A(2A) adenosine receptor.

Adenosine metabolism and cancer. Focus on “Adenosine downregulates DPPIV on HT-29 colon cancer cells by stimulating protein tyrosine phosphatases and reducing ERK1/2 activity via a novel pathway”.

A3 adenosine receptor as a target for cancer therapy.

The A3 adenosine receptor is highly expressed in tumor versus normal cells: potential target for tumor growth inhibition.

Differential effect of adenosine on tumor and normal cell growth: focus on the A3 adenosine receptor.

Elevated expression of A3 adenosine receptors in human colorectal cancer is reflected in peripheral blood cells.

The A3 adenosine receptor as a new target for cancer therapy and chemoprotection.

Induction of apoptosis by A3 adenosine receptor agonist N-(3-iodobenzyl)-adenosine-5′-N-methylcarboxamide in human leukaemia cells: a possible involvement of intracellular mechanism.

Adenosine A2B Receptor Blockade Slows Growth of Bladder and Breast Tumors.

Hypoxia-inducible adenosine A2B receptor modulates proliferation of colon carcinoma cells.

The A3 adenosine receptor agonist CF102 induces apoptosis of hepatocellular carcinoma via de-regulation of the Wnt and NF-kappaB signal transduction pathways.

CF102 an A3 adenosine receptor agonist mediates anti-tumor and anti-inflammatory effects in the liver.

Adenosine A1 receptor, a target and regulator of estrogen receptoralpha action, mediates the proliferative effects of estradiol in breast cancer.

Methylxanthines, such as caffeine and theophylline, can function as antagonists of adenosine receptors, and their stimulant actions occur primarily through this mechanism. Theophylline is a prescription medication to treat airway spasms in people with asthma or COPD. Caffeine is a mild stimulant. It can be found in many weight loss pills to boost the metabolism. But there are a number of additional situations where caffeine can serve important medical uses. Several studies have found connections between caffeine and cancer. Caffeine is similar in structure to adenosine, and binds to those receptors so that adenosine cannot bind. Caffeine acts mainly via blockade of adenosine receptors. In conclusion, targeting approaches that involve ARs will enhance the possibilities to cure cancer naturally, via the universally consumed substance that is caffeine.

Emerging adenosine receptor agonists – an update.

Methylxanthines, inflammation, and cancer: fundamental mechanisms.

Xanthines as adenosine receptor antagonists.

Caffeine and adenosine.

Analogues of caffeine and theophylline: effect of structural alterations on affinity at adenosine receptors.

Modulation of cellular response to anticancer treatment by caffeine: inhibition of cell cycle checkpoints, DNA repair and more.

Caffeine inhibits adenosine-induced accumulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and interleukin-8 expression in hypoxic human colon cancer cells.

Caffeine intake induces an alteration in human neutrophil A2A adenosine receptors.

Caffeine is a very common substance that is contained in coffee, tea, chocolate, soft drinks, and can also be purchased as capsules, tablets, or powder. An estimated 80% of the world’s population consumes a caffeine-containing substance daily. A typical 8-ounce (240-ml) cup of instant coffee contains about 100 mg of caffeine — about twice as much as a cup of tea or a 12-ounce (360-ml) can/bottle of soda. A 30-gram chocolate bar might contain as much caffeine as half a cup of tea. Pure caffeine can be obtained in powders, caplets or tablets in products like NoDoz, Stay Awake and Vivarin.

It’s generally agreed that consuming up to 300 mg of caffeine per day is safe. That’s roughly the amount of caffeine you would get from three cups (not mugs or big paper cups) of coffee. Consuming more than 300 mg caffeine per day may give you the “caffeine jitters.” Larger amounts of caffeine may make you irritable, sleepless and may even trigger anxiety and cause diarrhea. Some people are more sensitive to caffeine than are others. So we cannot suggest a universally safe dose. However, it is believed that the expected treatment effect of caffeine is time-dependent and dose-dependent. Some packages will use an age range to figure dose, but it is more effective to dose by weight. So, we recommend you take 4.5 mg per pound of body weight (for metric users, that’s 10mg per kilo). For example: a 133-pound woman would get about 600mg (133 X 4.5 =598) caffeine per day (200mg 3times daily) in combination with 5-LOX inhibitor such as BosturZym. BosturZym has synergistic effect with caffeine against cancer and leukemia. You can take them all together.

Lethal Enzyme 5-LOX and Cancer

Please Note: Caffeine in concentrated forms such as pills or powders can accidentally be taken insufficient quantities to cause nausea, vomiting, stomach upset, trouble sleeping, increased urination, or unconsciousness. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. A single box of Vivarin or No-Doze can be fatal if taken at one time. Although possible with coffee or other strongly caffeinated drink, it generally requires much more awareness of the large dosage before dangerous levels are reached.

        Oral Caffeine Dosages

• Threshold: 10 – 20 mg
• Common: 50 – 150 mg
• Strong: 150 – 400 mg
• Heavy: 400 + mg
• Lethal: 3-20 grams oral (estimated)
• LD50 (Lethal Dose): 192 mg/kg in rats. (LD50 = dose which will kill 50% of the tested animals. It is estimated that fatal doses for humans are between 3 and 20 grams of caffeine taken orally, depending on body weight and tolerance.

       Onset : 5 – 10 minutes
       Duration : 1.5 – 5 hours, Normal After Effects : up to 24 hours

In response to poor dietary choices, our bodies suffer an overload of AA, and the body increases production of enzymes like 5-Lipoxygenase (5-LOX) to remove AA. There are three main LOX enzymes that are known to be involved in the leukotriene pathway, 5-LOX, 12-LOX, and 15-LOX. Most attention has focused on 5-LOX, which appears to be the key enzyme when it comes to blocking leukotriene synthesis. 5-LOX is expressed mainly in leukocytes, dendritic cells and in foam cells of atherosclerotic tissue (in other cells synthesis is blocked by DNA methylation). 5-LOX is a key enzyme in the metabolism of AA to leukotrienes. 5-LOX converts AA to leukotrienes, which are able to enhance proliferation, increase survival, and suppress apoptosis of human cells. Leukotrienes are potent lipid mediators that are significantly involved in immunoregulation, asthma, inflammation and several allergic conditions. Inflammatory mediators such as leukotrienes cause an increased expression and re-distribution of proteins, characteristic of transformed cells, in normal cells. These alterations involve distinct upstream signaling mechanisms and lead to an altered rate of apoptosis and proliferation, changes that could increase the risk for a subsequent tumour development. These mediators could possibly explain the relation between inflammatory conditions and tumour development.

Roles of inflammation in cancer initiation, progression, and metastasis.

Regulation of inflammation in cancer by eicosanoids.

Eicosanoid signalling pathways in the development and progression of colorectal cancer: novel approaches for prevention/intervention.

Beta-adrenergic and arachidonic acid-mediated growth regulation of human breast cancer cell lines.

Structures and mechanisms of enzymes in the leukotriene cascade.

Leukotriene B4 creates a favorable microenvironment for murine melanoma growth.

5-LOX has been implicated in the development and progression of cancers including lung, liver, prostate, pancreatic, colorectal, brain, breast and esophageal cancers. Several pieces of experimental data form the basis for this hypothesis and suggest a correlation between 5-LOX expression and tumor cell viability. First, several independent studies documented an overexpression of 5-LOX in primary tumor cells as well as in established cancer cell lines. Second, addition of 5-LOX products to cultured tumor cells also led to increased cell proliferation and activation of anti-apoptotic signaling pathways. 5-LOX antisense technology approaches demonstrated impaired tumor cell growth due to reduction of 5-LOX expression. Lastly, pharmacological inhibition of 5-LOX potently suppressed tumor cell growth by inducing cell cycle arrest and triggering cell death via the intrinsic apoptotic pathway.

Lipoxygenase metabolism: roles in tumor progression and survival.

5-lipoxygenase: underappreciated role of a pro-inflammatory enzyme in tumorigenesis.

5-Lipoxygenase contributes to the progression of hepatocellular carcinoma.

Lipoxygenase-5 is overexpressed in prostate adenocarcinoma.

5-Lipoxygenase, a marker for early pancreatic intraepithelial neoplastic lesions.

Increased expression of 5-lipoxygenase is common in clear cell renal cell carcinoma.

5-LOX inhibitors induce programmed cell death by an enhanced membrane expression of TRAIL receptors on the membranes of cancer cells, and raise the possibility that the combination of 5-LOX inhibitor and TRAIL is a promising strategy for cancer treatment. In addition, these inhibitors also activate other death signaling pathways in
cancer cells.

Lipoxygenase inhibitors induce death receptor 5/TRAIL-R2 expression and sensitize malignant tumor cells to TRAIL-induced apoptosis.

Overexpression of 5-lipoxygenase in colon polyps and cancer and the effect of 5-LOX inhibitors in vitro and in a murine model.

Inhibition of 5-lipoxygenase triggers apoptosis in prostate cancer cells via down-regulation of protein kinase C-epsilon.

Inhibition of arachidonate 5-lipoxygenase triggers prostate cancer cell death through rapid activation of c-Jun N-terminal kinase.

Inhibition of 5-lipoxygenase pathway suppresses the growth of bladder cancer cells.

5-Lipoxygenase inhibitors attenuate growth of human renal cell carcinoma and induce apoptosis through arachidonic acid pathway.

Increased 5-lipoxygenase expression and induction of apoptosis by its inhibitors in esophageal cancer: a potential target for prevention.

Lipoxygenase inhibitors attenuate growth of human pancreatic cancer xenografts and induce apoptosis through the mitochondrial pathway.

The mechanisms of lipoxygenase inhibitor-induced apoptosis in human breast cancer cells.

Boswellia extracts emerged as the most prominent natural sources of 5-LOX-inhibiting compounds. AKBA (acetyl-keto-beta-boswellic acid), a principal component of boswellia, is a 5-LOX inhibitor. AKBA acts by numerous mechanisms to prevent cancer cells from proliferating. It induces apoptosis by switching on death receptor on cancer cell surfaces by activation of apoptotic pathways inside cancer cells. AKBA also activate the PI3K/Akt pathway and inhibition of the PI3K pathway significantly enhances AKBA-induced apoptosis. AKBA suppresses activity of CXCR4 that cancer cells use to trigger the metastases. AKBA enhances apoptosis induced by cytokines and chemotherapeutic agents, inhibits invasion, and suppresses osteoclastogenesis through inhibition of NF-kappaB-regulated gene expression. And AKBA further inhibits tumor growth by suppressing a growth factor, VEGF (vascular endothelial growth factor), required by cancers to grow necessary new blood vessels. Boswellic acid also blocks important signaling molecules required for cancer cell replication. Boswellia oil extracts can distinguish between healthy and cancerous tissue, suppressing tumor cell viability but sparing normal cells.

Unfortunately dietary boswellia ectracts are characterized by poor solubility and bioavailability, which means that most of what we swallow goes directly into our gastrointestinal area and is expelled.

BosturZym contains an “adaptogenic” mixture of fermented herbal compounds including boswellic acid (AKBA), curcumin and turmerine in a synergistic proprietary formula. BosturZym is the one and only product in the world that has perfect solubility and bioavailability of these compounds enough to induce apoptosis in cancer cells.

Acetyl-11-keto-beta-boswellic acid (AKBA): structure requirements for binding and 5-lipoxygenase inhibitory activity.

Protective effects of nimesulide (COX Inhibitor), AKBA (5-LOX Inhibitor), and their combination in aging-associated abnormalities in mice.

Acetyl-keto-beta-boswellic acid induces apoptosis through a death receptor 5-mediated pathway in prostate cancer cells.

Acetyl-11-keto-beta-boswellic acid induces apoptosis in HL-60 and CCRF-CEM cells and inhibits topoisomerase I.

Acetyl-11-keto-beta-boswellic acid potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis by suppressing NF-kappa B and NF-kappa B-regulated gene expression.

Acetyl-11-keto-beta-boswellic acid inhibits prostate tumor growth by suppressing vascular endothelial growth factor receptor 2-mediated angiogenesis.

Boswellic acid blocks signal transducers and activators of transcription 3 signaling, proliferation, and survival of multiple myeloma via the protein tyrosine phosphatase SHP-1.

Boswellic acid suppresses growth and metastasis of human pancreatic tumors in an orthotopic nude mouse model through modulation of multiple targets.

Boswellia sacra essential oil induces tumor cell-specific apoptosis and suppresses tumor aggressiveness in cultured human breast cancer cells.

Frankincense oil derived from Boswellia carteri induces tumor cell specific cytotoxicity.

In addition to the direct inhibition of 5-LOX activity by Boswellia extracts, the sleep hormone melatonin made by body’s pineal gland is able to activate opioid receptors indirectly to inhibit expression of 5-LOX and Cox 2. Melatonin inhibits the synthesis of the 5-LOX via its activation of nuclear receptors.

Melatonin: a hormone that modulates pain.

The nuclear receptor for melatonin represses 5-lipoxygenase gene expression in human B lymphocytes.

Esculetin, a phenolic compound, acts as a 5-LOX inhibitor. Esculetin is reported to display anti-inflammatory and antioxidant properties, as well as induce cell cycle arrest and apoptosis. In the presence of Esculetin and HA14-1 expression of the death receptor DR4 has been observed to be upregulated and extracellular-regulated kinase (ERK) to be activated. Other studies suggest that Esculetin upregulates death receptor DR5 protein expression, and enhances TRAIL-induced apoptosis. Additionally, reports demonstrate that Esculetin also inhibits the activity of 12-LOX, and decreases leukotriene biosynthesis during 5-LOX inhibition.

Binding investigation of human 5-lipoxygenase with its inhibitors by SPR technology correlating with molecular docking simulation.

Intestinal anti-inflammatory activity of esculetin and 4-methylesculetin in the trinitrobenzenesulphonic acid model of rat colitis.

Induction of apoptosis by esculetin in human leukemia U937 cells: roles of Bcl-2 and extracellular-regulated kinase signaling.

Esculetin enhances TRAIL-induced apoptosis through DR5 upregulation in human oral cancer SAS cells.

Caffeic Acid is an endogenous phenolic phytochemical that exists in plants and many foods. A major metabolite product upon hydrolization of chlorogenic acid, caffeic acid inhibits a number of lipoxygenases such as 5-LOX, in a non-competitive manner, and 12-LOX inhibiting leukotriene synthesis resulting in further inhibition of immunoregulation. At high doses Caffeic Acid has also been shown to inhibit arachidonic acid metabolism in platelets, as well as stimulating prostaglandin synthesis.

Caffeic acid derivatives: in vitro and in vivo anti-inflammatory properties.

Novel and therapeutic effect of caffeic acid and caffeic acid phenyl ester on hepatocarcinoma cells: complete regression of hepatoma growth and metastasis by dual mechanism.

Anti-HIV activities of natural antioxidant caffeic acid derivatives: toward an antiviral supplementation diet.

Analogues of N-hydroxycinnamoylphenalkylamides as inhibitors of human melanocyte-tyrosinase.

Caffeic acid, a phenolic phytochemical in coffee, directly inhibits Fyn kinase activity and UVB-induced COX-2 expression.

Manassantin, a dilignan isolated from Saururus chinensis, has been suggested to exert various biological activities, such as neuroleptic, anti-inflammatory and human acyl-CoA: cholesterol acyltransferase (ACAT) inhibitory activities. Manassantin inhibits 5-LOX translocation and leukotriene biosynthesis.

Methy jasmonate, a plant stress hormone, also specifically inhibits the activity of the 5-LOX. This induces apoptosis in prostate cancer cell lines. Jasmonates act as signal transduction intermediates when plants are subjected to environmental stresses such as UV radiation, osmotic shock and heat.

The prescription drug Zileuton (trade name ZYFLO) is used for the maintenance treatment of asthma. Zileuton is an orally active inhibitor of 5-LOX, and thus inhibits leukotrienes.

Manassantin A isolated from Saururus chinensis inhibits 5-lipoxygenase-dependent leukotriene C4 generation by blocking mitogen-activated protein kinase activation in mast cells.

Methyl jasmonate induced apoptosis in human prostate carcinoma cells via 5-lipoxygenase dependent pathway.

Jasmonates are phytohormones with multiple functions, including plant defense and reproduction.

BIOSYNTHESIS AND ACTION OF JASMONATES IN PLANTS.

The 5-lipoxygenase inhibitor, zileuton, suppresses prostaglandin biosynthesis by inhibition of arachidonic acid release in macrophages.

Cox-2, the inducible isoform of Cox (cycloxygenase), has emerged as the key enzyme regulating inflammation, and promises to play a considerable role in cancer. The combination of Cox-2 inhibitors and specific 5-LOX inhibitors may be an effective method for controlling cancer development. Some dual COX and 5-LOX inhibitors are chebulagic acid, quercetin, green tea catechins, neem, turmeric (curcumin), milk thistle (silymarin and silibinin), Flavocoxid and BosturZym. Celebrex, generic drug name celecoxib, is the only Cox-2 selective NSAID currently on the market. 5-LOX inhibitors alone or in combination with dual COX /5-LOX inhibitors  and Celebrex could be useful to prevent local recurrence after resection or as palliative option for advanced cancer.

Enhancing antitumor effects in pancreatic cancer cells by combined use of COX-2 and 5-LOX inhibitors.

Simultaneous inhibition of COX-2 and 5-LOX activities augments growth arrest and death of premalignant and malignant human lung cell lines.

Chebulagic acid, a COX-LOX dual inhibitor isolated from the fruits of Terminalia chebula Retz., induces apoptosis in COLO-205 cell line.

Flavocoxid, a dual inhibitor of cyclooxygenase and 5-lipoxygenase, blunts pro-inflammatory phenotype activation in endotoxin-stimulated macrophages.

A medicinal extract of Scutellaria baicalensis and Acacia catechu acts as a dual inhibitor of cyclooxygenase and 5-lipoxygenase to reduce inflammation.

Eicosanoid modulation in advanced lung cancer: cyclooxygenase-2 expression is a positive predictive factor for celecoxib + chemotherapy–Cancer and Leukemia Group B Trial 30203.

Licofelone, a dual COX/5-LOX inhibitor, induces apoptosis in HCA-7 colon cancer cells through the mitochondrial pathway independently from its ability to affect the arachidonic acid cascade.

Regulation of COX and LOX by curcumin.

Evaluation of antioxidant and inhibitory activities for different subclasses flavonoids on enzymes for rheumatoid arthritis. 

Even if drug therapy successfully blocks the Cox-2 and 5-LOX enzyme systems, arachidonic acid can still be converted into other damaging molecules, such as epoxy derivatives. So, another approach to treating the diseases involving eicosanoids seems desirable. Eicosanoids are produced primarily from arachidonic acid that has been released from cell membrane phospholipids. Diets low in arachidonic acid, omega-6 fatty acids, saturated fats, high-glycemic food and overcooked food can suppress inflammatory factors in the body. Not all of the phospholipids in cell membranes include arachidonic acid, only those that were derived from certain dietary fatty acids, mainly linoleic acid. The concept of dietary control over these diseases is based, in part, on starving the eicosanoid system by reducing the fatty acids (specifically, the polyunsaturated fatty acids such as soybean oil, corn oil, safflower oil, grape seed oil, poppy oil and sunflower oil) that can eventually make arachidonic acid, thereby slowing down the production of eicosanoids when a stimulus occurs. Fish oil, flaxseed oil and perilla seed oil help to lower Cox-2 and 5-LOX activity in the body.

In comparison, immunotherapy revolves around bolstering the body’s own defences so that they can mount an effective attack on cancer. Everyone has the power within them to heal cancer and all we have to do is to find a way to unlock our inner potential. Cancer immunotherapy is the stimulation, support, or other assistance of the immune system to help fight cancer. Historical data show that the immune system clearly plays a role in cancer progression. For example, immunosuppression is associated with cancer development. In fact, cancer is more likely to occur in people who take immunosuppressive medications than in people with normal immune function.

Cell death can be achieved by fundamentally different mechanisms, apoptosis, necrosis and autophagy. Through which molecular and cellular mechanisms do cells die in normal tissues? Answering this question is of prime medical importance because homeostatic cell death is an important tumor suppressor mechanism, meaning that a reduced propensity to die is one of the hallmarks of cancer cells. Apoptosis, or programmed cell death, can indeed be considered as a constitutive anti-cancer mechanism that seems to be defective in more than 50% of cancers.When a cancer cell grows it activates two different pathways. The first stimulates cellular growth while the second, acting like a safety net, prevents the activated cells from dying from programmed cell death.

There is a complex interaction between normal cellular growth and cell death if anything goes wrong. The second pathway protects the cells from dying prematurely. If we want to kill cancer cell, we need to inactivate its growth while inhibiting its ability to protect itself from small or large problems in its biochemistry. So, in brief, we need to induce as many problems as we can in its normal growth pathway, while simultaneously blocking its ability to adapt. Major tumor associated genes/pathways such as RAS, PI3K/AKT might not only decrease the overall sensitivity to chemotherapy but also directly effect cell death mechanisms. Hence, the failure to eliminate mutated (or epigenetically modified) cancer cells (or their precursors) by programmed cell death is an obligate step of multi-step carcinogenesis.

Cell death can be induced by a family of death receptors including Fas, TNF (tumor necrosis factor) and TRAIL (Tumor necrosis factor-related apoptosis inducing ligand). One of the main mechanisms by which immune effector cells kill is by induction of apoptosis by Fas/FasL interactions. Fas (CD95 or Apo-1) is a transmembrane protein belonging to the tumor necrosis factor receptor (TNFR) family of cell surface molecules. Its ligation with specific agonistic antibodies or its cognate ligand (FasL or CD95L) induces the activation of a cascade of cysteines proteases, called caspases, and ultimately of nucleases that result in apoptotic cell death in many cell lineages.

The recent identification of the Fas and FasL as a major regulator of both apoptosis and immune function has provided insight into an attractive mechanism of tumor escape from immune clearance. Fas is induced on activated T lymphocytes and targets them for subsequent elimination by FasL-expressing cells. Given the importance of the Fas/FasL system as a major mechanism by which T lymphocytes kill tumor cells, it is not surprising that tumor cells can use this system to evade immune recognition. Tumor cells may acquire resistance to Fas-mediated apoptosis by down-regulating Fas expression, secreting decoy receptors to block FasL on activated T lymphocytes, or by altering intracellular mechanisms mediating Fas-induced apoptosis. There’s another strategy. When some tumor cells encounter activated T cells bearing Fas, FasL/Fas interactions induce apoptosis of the T cell thereby terminating the immune response and providing immune privilege to tumors.

TNF is a cytokine involved in systemic inflammation and is a member of a group of cytokines that stimulate the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by other cell types as well. The primary role of TNF is in the regulation of immune cells. Unfortunately, two of these pathways, TNF and Fas, are toxic to both cancerous and normal cells. This makes activators of these pathways somewhat dangerous. Under certain circumstances, expression of FasL results in tumor removal, and overexpression of FasL results in an intense inflammatory response in several experimental models.

Life and death by death receptors.

A novel role of microtubular cytoskeleton in the dynamics of caspase-dependent Fas/CD95 death receptor complexes during apoptosis.

The extracellular glycosphingolipid-binding motif of Fas defines its internalization route, mode and outcome of signals upon activation by ligand.

Identification of a lysine-rich region of Fas as a raft nanodomain targeting signal necessary for Fas-mediated cell death.

Involvement of raft aggregates enriched in Fas/CD95 death-inducing signaling complex in the antileukemic action of edelfosine in Jurkat cells.

The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cells.

Targeting the Fas/Fas ligand pathway in cancer.

The CD95 receptor: apoptosis revisited.

CD95L/FasL and TRAIL in tumour surveillance and cancer therapy.

TRAIL (Tumor necrosis factor-related apoptosis inducing ligand) is a death pathway. TRAIL is normally expressed in the human immune system and plays a critical role in antitumor immunity. TRAIL was cloned in 1995 and subsequent studies revealed its physiological functions in antitumor innate and adaptive immunity. TRAIL is required for natural killer cell-mediated immunosurveillance against the tumor progression and metastasis. TRAIL interacts with the death receptors, DR4 and DR5, and activates intracellular apoptotic pathway in cancer cells. Interestingly, it is totally non-toxic to normal cells, while retaining its ability to kill highly chemotherapy resistant cancer and leukemia cells. TRAIL can kill any cancer or leukemia cell regardless of their degree of malignancy. The TRAIL death pathway has emerged as an important therapeutic strategy. But activating TRAIL successfully isn’t easy. We need to stimulate TRAIL production and expression of the DR4 and DR5. We also need to overcome all the biochemical pathways that block TRAIL efficacy. Considerable numbers of cancer cells, especially some highly malignant tumors, are resistant to apoptosis induction by TRAIL, and some cancer cells that were originally sensitive to TRAIL-induced apoptosis can become resistant after repeated exposure (acquired resistance).

TNF-related apoptosis-inducing ligand (TRAIL): a new path to anti-cancer therapies.

TRAIL: a sword for killing tumors.

TRAIL death receptors and cancer therapeutics.

TRAIL as a target in anti-cancer therapy.

Mechanisms of resistance to TRAIL-induced apoptosis in cancer.

Biological membranes are sheets of lipids that form barriers between compartments within cells or, in the case of the plasma, between the cell and its external environment. Membrane fluidity is a characteristic of cell membranes that depends on their lipid and protein composition. Membranes of tumor cells have been found to posess higher fluidity than membranes of nontumor cells. The types of lipids in a cell membrane can vary and abruptly form small islands of specific types, known as lipid rafts. Lipids are also linked to many proteins and, once attached, move the protein to specific places in membranes. Localization of the death receptor Fas to specialized membrane microdomains is crucial to Fas-mediated cell death signaling.

Palmitoylation is the posttranslational addition of the 16-carbon palmitate group to specific cysteine residues of proteins via a labile thioester bond. Unlike other forms of lipidation, such as myristoylation and prenylation, palmitoylation is reversible which allows for dynamic regulation of protein-membrane interactions, trafficking between membrane compartments. The attachment of palmitic acid to the amino acid cysteine via thioester linkage (S-palmitoylation) is a reversible post-translational modification that occurs on diverse cellular proteins. Palmitoylation modulates protein function by facilitating targeted membrane association, interaction with other proteins, and determining subcellular localization. Intracellular palmitoylation reactions are mediated by a family of recently identified palmitoyl transferases.

Fas/CD95 death receptor and lipid rafts: new targets for apoptosis-directed cancer therapy.

Lipid rafts and Fas/CD95 signaling in cancer chemotherapy.

Palmitoylation of membrane proteins (Review).

The fat controller: roles of palmitoylation in intracellular protein trafficking and targeting to membrane microdomains (Review).

Palmitoylation of intracellular signaling proteins: regulation and function.

Palmitic acid, also called hexadecanoic acid, is one of the most common saturated fatty acids. It is found in palm oil but also in butter, cheese, milk and meat. Fatty acid synthase (FASN) synthesizes palmitic acid in the body. Palmitic acid is converted to ceramide, the death lipid. Ceramide is made from palmitic acid and the amino acid serine. Neither of these molecules is plentiful in our diets. Ceramide is also used as a building block for the synthesis of other lipids. Since ceramide is a toxic lipid and is involved in the induction of apoptosis (programmed cell death), its synthesis is thghtly controlled in the body.

Fatty acid synthase drives the synthesis of phospholipids partitioning into detergent-resistant membrane microdomains.

Differential regulation of ceramide in lipid-rich microdomains (rafts): antagonistic role of palmitoyl:protein thioesterase and neutral sphingomyelinase 2.

Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance.

Metabolism of short-chain ceramide by human cancer cells–implications for therapeutic approaches.

Palmitoylation is required for efficient Fas cell death signaling. S-palmitoylation of Fas in its cytoplasmic domain, which consists of the reversible addition of a palmitic acid to a cysteine, represents an essential signal targeting Fas to rafts. Palmitoylation allows Fas to associate with the cytoskeletal protein ezrin, reported to be critical for Fas mediated cell death. Indeed, the FasL-induced internalization of Fas receptor has been shown to occur in the clathrin-dependent pathway and is a prerequisite for DISC (death-inducing signalling complex) formation, which occurs predominantly in endosomes. Palmitoylation of TRAIL death receptor DR4 is also required for efficient TRAIL-induced cell death signaling. If the TNF, FAS and TRAIL death receptor pathways worked as designed, there would be no cancer, leukemia or autoimmune diseases. These receptors are responsible for killing defective cells by the non-inflammatory process of programmed cell death. However, some other palmitoylated proteins such as Wnt and Hedgehog proteins are involved in cellular differentiation and growth.

Palmitoylation is required for efficient Fas cell death signaling.

Palmitoylation of human FasL modulates its cell death-inducing function.

The extracellular glycosphingolipid-binding motif of Fas defines its internalization route, mode and outcome of signals upon activation by ligand.

Lipid raft localization and palmitoylation: identification of two requirements for cell death induction by the tumor suppressors UNC5H.

Palmitoylation of CD95 facilitates formation of SDS-stable receptor aggregates that initiate apoptosis signaling.

Palmitoylation of the TRAIL receptor DR4 confers an efficient TRAIL-induced cell death signalling.

Overexpression of fatty acid synthase is associated with palmitoylation of Wnt1 and cytoplasmic stabilization of beta-catenin in prostate cancer.

Membrane targeting of palmitoylated Wnt and Hedgehog revealed by chemical probes.

T lymphocytes play an important role in immune surveillance against intracellular pathogens and tumors. Signal transduction through CD90 regulates cytokine production by CD4+ T helper cells, as well as expression of TRAIL, FasL, granzyme B and perforin by CD8+ cytotoxic T cells (CTL), and the induction of CD4+ regulatory T cells. Cytokines, including IL-2, IL-12, and IFN-gamma, are important inducers of the cytotoxic effector molecules that are involved in tumor cell and allograft destruction by the cell-mediated immune response. Granzymes and perforin are known to be important mediators of target cell destruction. TRAIL and FasL expressed by CTL also trigger apoptosis in susceptible target cells. Regulatory T cells are essential for the maintenance of immunologic homeostasis.

Current concepts of tumor-infiltrating lymphocytes in human malignancies.

Signaling defects in anti-tumor T cells.

Antimicrobial and immunoregulatory effector mechanisms in human endothelial cells. Indoleamine 2,3-dioxygenase versus inducible nitric oxide synthase.

Positive and negative consequences of soluble Fas ligand produced by an antigen-specific CD4(+) T cell response in human carcinoma immune interactions.

A critical role for granzymes in antigen cross-presentation through regulating phagocytosis of killed tumor cells.

Reciprocal granzyme/perforin-mediated death of human regulatory and responder T cells is regulated by interleukin-2 (IL-2).

Anticancer properties of the IL-12 family–focus on colorectal cancer.

Active immunity may be the ideal of immunotherapy. Coley’s toxin was the first documented attempt in the U. S. to treat cancer by stimulating the immune system. It was first developed in the 1890s by William B. Coley, MD, who noted that patients who developed bacterial infections after surgery for sarcoma had visible regressions of their cancers. Because using live bacteria was dangerous and because he determined that immune reactions depended upon the toxins of the bacteria rather than the actual bacteria, he eventually mixed toxins of the Streptococcus and Bacillus prodigiosus bacteria. Some regressions of cancer were reported among patients treated with these toxins from the 1890s until the 1950s when the treatment largely fell into disuse with the advent of radiotherapy and chemotherapy. The stimulated human immune system is a whirling tempest of different physiological and biochemical responses, and even now there’s much uncertainty about how Coley’s Toxins modified this complex mechanism to better attack its cancerous target.

We know now that tumors are immunogenic. The question is why, if tumors are immunogenic, do cancers grow? We know an immune response is elicited, yet what prevents the immune response from obliterating the cancer? When cells become cancerous they produce new, unfamiliar antigens. The immune system cells recognize marker proteins (antigens) from the foreign agents and produce proteins (antibodies) that interact with the antigen and ultimately destroy them. Another way the immune system works is by sensitizing a class of immune cells, the T-cells to recognize the foreign agents and destroy them. The immune cells recognize these cells as foreign because of the presence of surface markers. All cells have surface markers. Most tumor antigens are “self” proteins, rendering them weakly immunogenic. Our immune systems tolerate self-proteins, and tolerance is a major mechanism by which cancer can evade immune recognition.

Tumor cells must develop strategies to avoid clearance by the immune system to survive, expand their populations, and metastasize. As tumors grow, they secrete immunosuppressant factors. Thus, tumor cells may escape immune clearance by altering immune recognition or by modulation of the cytotoxic response. This immunomodulatory effect occurs directly, by viral proteins binding to immune receptor molecules and thus preventing their expression on the surface of the virally infected cell, or by tumors secreting factors that downregulate immune activation.

Choosing a conventional cnacer treatment is not easy. Conventional treatments, such as chemotherapy and/or radiation therapy, do nothing to eliminate the cause or prevent recurrence of cancer. But there is hope. With natural phytochemicals and anti-cacer agents, we can now stimulate death receptor pathways, block many of the anti-cell death pathways that inhibit death receptor efficacy and stimulate the anti-cancer immune response. We can also modulate the anti-cancer immune response, thus leading to better immune surveillance.

A number of naturally occurring compounds (phytochemicals) isolated from herbs, fruits and wild mushrooms are able to kill neoplastic cells through a variety of mechanisms. In many cases, the anti-cancer activities of phytochemicals involve inhibitory effects on the activation of transcription factors that promote tumor cell survival, metastasis and resistance to induction of apoptotic cell death.

Induction of apoptotic cell death by ursolic acid through mitochondrial death pathway and extrinsic death receptor pathway in MDA-MB-231 cells.

Ursolic acid induces PC-3 cell apoptosis via activation of JNK and inhibition of Akt pathways in vitro.

Involvement of mitochondria and recruitment of Fas/CD95 signaling in lipid rafts in resveratrol-mediated antimyeloma and antileukemia actions.

Resveratrol enhances the expression of death receptor Fas/CD95 and induces differentiation and apoptosis in anaplastic large-cell lymphoma cells.

Lupulone, a hop bitter acid, activates different death pathways involving apoptotic TRAIL-receptors, in human colon tumor cells and in their derived metastatic cells.

Quercetin enhances TRAIL-mediated apoptosis in colon cancer cells by inducing the accumulation of death receptors in lipid rafts.

Sulforaphane blocks hypoxia-mediated resistance to TRAIL-induced tumor cell death.

Resveratrol induces apoptosis of human nasopharyngeal carcinoma cells via activation of multiple apoptotic pathways.

Induction of apoptosis by rhapontin having stilbene moiety, a component of rhubarb (Rheum officinale Baillon) in human stomach cancer KATO III cells.

Activation of multiple apoptotic pathways in human nasopharyngeal carcinoma cells by the prenylated isoflavone, osajin.

The role of nutraceuticals in the regulation of Wnt and Hedgehog signaling in cancer.

Current findings, future trends, and unsolved problems in studies of medicinal mushrooms.

Mushroom lectins: current status and future perspectives.

The good news is that we are getting close to a true, non-toxic and effective natural anti-cancer/ anti-leukemia formula. Alternative cancer treatments really work. Most of the trials have confirmed the clinical efficacy of Hepazym immunotherapy in patients with lung cancer, liver cancer, colorectal cancer and lymphoma. What we try to achieve with active immunity induced by Hepazym immunotherapy is an endogenous immune response, where the immune system is primed to recognize the tumor as foreign. This approach has been successful in patients with liver cancer, lung cancer, colon cancer and lymphoma, as their immune systems are unable to mount a sufficient response. In the past several years, efforts have focused on using active immune therapies in patients with minimal disease. However, we have seen that the immune system can be quite functional despite advanced stage cancer when the patient has been treated to maximal response.

We have recently shown that Hepazym activates the extrinsic pathway of apoptosis in several different human cancer cells, without harming normal cells. Hepazym shows induction of apoptosis in T leukemia cells. In addition, Hepazym inhibits the proliferation and migration of human endothelial cells, and also inhibits growth factor-stimulated blood vessel development. Hepazym might therefore be able to reduce tumor progression by both a direct cytotoxic effect on the cancer cells and by inhibiting the development of tumor vasculature.  Hepazym offers a number of potential advantages over conventional chemotherapeutic agents. Hepazym immunotherapy is nontoxic and is predicted to be effective against multidrug-resistant variants of cancer cells. Hepazym therefore show potential for the treatment of metastatic cancer.

Our goal is to reduce cancer to the lowest common demoninator so it can be killed with the most basic of weapons. And Hepazym immunotherapy fulfills that goal perfectly. Keep in mind that this immunotherapy applies to all cancers and leukemias. Many people have contacted us after the fact and have told us that they or their loved ones have experienced major benefits, including the reduction in size, or complete disappearance of abnormal growths, when they took enough of Hepazym and Hepazym-F (Fermented Medicinal Mushroom Extracts, Liquid Herbal Minerals) for a long enough period of time.

Case Report: Liver Tumor

A 49-year-old male, South Korean, presented with Stage II hepatocellular carcinoma (liver cancer) caused by HBV. In February 2011, the surgery took place and was a success. In June 2011, cancer has recurred. Serum DCP (PIVKA II) level elevated to 110. He began taking 40 ml (10 ml 4 times) of Hepazym and 20 ml (10 ml twice) of Hepazym-F daily, and the hospital treatment was discontinued. As of September 2011, serum DCP (PIVKA II) level markedly decreased to normal range. The production of Interleukin-2 (IL-2) in his body multiplied because of Hepazym administration. IL-2 has shown antineoplastic activity and has also an antiviral effect. By November 2011 the tumor had disappeared.

Conclusion: The decrease of serum DCP (PIVKA II) level and the elevated serum level of IL-2 during immunotherapy with Hepazym predicts a possible new therapeutic option for HBV and HCV induced liver cancer and chronic viral infections.

With over years of safe use, the effects of the herbs in Hepazym have now been proven to be true. Of course today we know mechanism of the herbal synergy of the Hepazym formula supports the body’s natural healing mechanisms by activating all of the body’s natural healing pathways (immune system, digestive, circulatory, lymphatic, liver, bowels, kidneys, skin, and lungs). The healing synergy of the phytochemicals, super saccharides, immune molecules, antimicrobial peptides, organic plant based enzymes, pre- and probiotics and antioxidants in the herbs comprising Hepazym gently enhances the natural ongoing healing systems of the body, bringing them back to a more optimal state of activity. It does not “force” the body into an unnatural healing mode.  

Hepazym can be used daily as a natural cellular defense, liver cleanse and lung cleanse, gastrointestinal support, immune support and immune modulation for treatment of cancer and chronic infections. Most of the healthy cells in the body can and will regenerate, if there are enough of them and the body is not too exhausted. Hepazym immunotherapy brings the body back into balance, starting a rebuilding and re-education process, so there is the potential for restoration. Keep in mind that Hepazym immunotherapy is an herbal remedy, and as such, although it is very effective, it can take time. So perseverance is needed.

It is difficult to identify how long it will take before you notice a measurable difference in your health after starting on Hepazym immunotherapy. There are many factors involved, but usually some benefits are noticed within two weeks, providing it is taken consistently. It will make your urine more yellow. This is a normal process and is not harmful, so in turn your urine turns the same color. There can be a short period when weakness or nausea may be felt. This is when the body is discharging toxins and poisons that have been gathered, and getting rid of them. Persevere and this will pass shortly. Although everyone responds individually to Hepazym immunotherapy, there are many positive signs of help that encourage:

• Appetite may improve as taste buds, diminished by treatment, are restored.
• The pain level may reduce or disappear altogether.
• Energy may increase, as the detoxifying takes place.
• Bodily functions, such as anti-cancer immune response, may normalize themselves.
• Test results may also show marked improvement.
• Sleep patterns may improve, as it is a natural sedative, and calms the body.
• Outlook in life may become more positive, giving you a sense of well-being.