Herbalzym

Sanguinarine induces apoptosis and inhibits growth of cancer cells

May 21, 2013, Featured in Cancer and Natural Medicines, 0 Comments

Bloodroot (Sanguinaria canadensis) has been used historically by some Native American tribes as a medicinal agent to stimulate the digestive system. It has also been used medicinally as a remedy for fevers, as an expectorant for chronic bronchitis and as a local application in chronic eczema, especially when secondary to varicose ulcers.

Bloodroot is generally prescribed as an external treatment as it is poisonous if ingested in large amounts. In toxic doses, it causes burning in the stomach, intense thirst, vomiting, faintness vertigo, intense prostration with dimness of eyesight. Bloodroot grows primarily in North America and in India. Sanguinarine, the major active compound found in bloodroot, is a very impressive natural medicine. Sanguinarine is a benzophenanthrene alkaloid. It has also been …

Topical application of purified EGCG can effectively kill metastatic cancer cells

April 1, 2013, Featured in Cancer and Natural Medicines, 0 Comments

Much of the cancer chemopreventive properties of green tea are mediated by EGCG. Cancer cells survive by using multiple pathways. But EGCG is so powerful, it cuts those pathways off. Apparently, EGCG functions as a powerful antiangiogenic and antitumor agent and as a modulator of tumor cell response to chemotherapy. EGCG induces apoptosis and promotes cell growth arrest by altering the expression of cell cycle regulatory proteins, activating killer caspases, and suppressing oncogenic transcription factors and pluripotency maintain factors.

EGCG is also able to induce proteasome inhibition in whole cells. Since the inhibition of the proteasome blocks the activation of NF-kB, it is logical to conclude that proteasome inhibitors such as EGCG would have a strong therapeutic effect against cancer, lymphoma and leukemia….

Revisiting the role of EGCG-MAX (Pure Liquid 95% EGCG) in the treatment of all cancers and leukemias

March 6, 2013, Featured in Cancer and Natural Medicines, 0 Comments

EGCG (epigallocatechin gallate) is the most abundant and perhaps most important catechin found in green tea (camellia sinensis). Catechins are polyphenolic antioxidant plant metabolites and belong in the flavonoid family. EGCG functions as a powerful antioxidant, preventing oxidative damage in healthy cells, but also as an antiangiogenic and antitumor agent and as a modulator of tumor cell response to chemotherapy.

There is a huge literature showing that EGCG kills cancer cells of all kinds. EGCG reactivates epigenetically silenced genes in cancer cells and induces apoptosis and promotes cell growth arrest, by altering the expression of cell cycle regulatory proteins, activating killer caspases, and suppressing nuclear factor kappa-B (NF-kB) activation.

The majority of human cancers demonstrate the inactivation of the p53 pathway. p53 …

Methionine dependency of cancer cells and dietary methionine restriction

January 5, 2013, Featured in Cancer and Natural Medicines, 0 Comments

Metabolic abnormalities of tumor cells offer opportunities of therapeutic targeting. Tumor cells are more sensitive to methionine restriction than normal tissues, a phenomenon known as methionine auxotrophy. Methionine is one of the essential amino acids with many key roles in mammalian metabolism such as protein synthesis, methylation of DNA and polyamine synthesis but cannot be produced in the body, and so must be provided through our diet.

Many cancer cells and primary tumors have absolute requirements for methionine. Methionine-dependent increase in tumor cells is a specific metabolic defect. The biochemical mechanism for methionine dependency has been studied extensively, but the fundamental mechanism remains unclear. Methionine starvation can powerfully modulate DNA methylation, cell cycle transition, polyamines and antioxidant synthesis of tumor cells. Therefore, low methionine in the diet may be an important …

♪♫ HAPPY NEW YEAR 2013!

December 28, 2012, Featured in Cancer and Natural Medicines, 0 Comments

Happy Happy New Year to all of you….

.

Fermented Bitter Melon Extract can prevent or treat a variety of cancers

October 16, 2012, Featured in Cancer and Natural Medicines, 0 Comments

Bitter melon is a member of the Cucurbitaceae family (cucumbers, pumpkins and watermelons). The bitter melon fruit, sometimes called bitter gourd or wild cucumber, grows in tropical and sub-tropical climates. It is very nutritious vegetable having high therapeutic value. It is used both as food and in medicine to treat type2 diabetes, cancer, infections, HIV (AIDS), menstrual disorder and immune disorders.

Chemical constituents from whole plants, fruits, and seeds of bitter melon (Momordica charantia) have been isolated and described as following:

Glycosides: momordin, charantin
Alkaloids: momordicin
Others: polypeptide-P
Oils (seed only): stearic, linoleic, oleic acids
Glycoproteins: alpha-momorcharin, beta-momorcharin, lectins
Others: vicine (pyrimidine nucleoside), protein MAP30
Cucurbitane triterpenoids

Previously, the researchers have reported that extract of bitter melon has sugar- and fat-lowering properties. The compounds present in …

Glycolytic enzyme inhibitors effectively kill cancer cells – Part 3

September 24, 2012, Featured in Cancer and Natural Medicines, 0 Comments

Signal transducer and activator of transcription-3 (STAT3) protein is a member of the STAT family of transcription factors which are initially located in the cytoplasm in their inactive form. STAT proteins are part of a group that is sometimes called DNA- binding factors. These proteins bind to DNA sequences, and therefore control the transcription of information from DNA to mRNA. A variety of growth factors and cytokines activate STAT3 by phosphorylating the tyrosine residue in the STAT3 transactivation domain. Phosphorylated STAT3 (p-STAT3) then translocates into the nucleus and induces the expression of a wide variety of target genes involved in tumorigenesis.

Tumor cells depend on STAT3 for continued rapid growth and avoidance of apoptosis. STAT3 is constitutively activated in a wide variety of tumours, including colorectal cancer, liver cancer, breast cancer, …

Glycolytic enzyme inhibitors effectively kill cancer cells – Part 2

September 11, 2012, Featured in Cancer and Natural Medicines, 0 Comments

As discussed in our previous article, PFK1 (phosphofructokinase type 1) is a major regulatory enzyme in glycolysis.

Anti-tumor activity of Herbalzym Vinegar by disrupting cancer cell metabolism

PFK1 is an allosteric enzyme made of 4 subunits and controlled by many activators and inhibitors. PFK-1 catalyzes the important “committed” step of glycolysis, the conversion of fructose 6-phosphate and ATP to fructose 1,6-bisphosphate and ADP.

PFK1 is allosterically inhibited by high levels of ATP but AMP reverses the inhibitory action of ATP. Therefore, the activity of the enzyme increases when the cellular ATP/AMP ratio is lowered. Glycolysis is thus stimulated when energy charge falls. PFK1 has two sites with different affinities for …

Glycolytic enzyme inhibitors effectively kill cancer cells – Part 1

September 9, 2012, Featured in Cancer and Natural Medicines, 0 Comments

The Warburg effect describes a pro-oncogenic metabolism switch such that cancer cells take up more glucose than normal tissue and favor incomplete oxidation of glucose even in the presence of oxygen. Most cancer cells exhibit increased glycolysis (the Warburg effect) and use this metabolic pathway for generation of ATP as a main source of their energy supply. A number of studies suggest several possible mechanisms by which this metabolic alteration may evolve during cancer development. These mechanisms include mitochondrial defects and malfunction, adaptation to hypoxic tumor microenvironment, oncogenic signaling, and abnormal expression of metabolic enzymes.

The glycolytic switch occupies a privileged position in the aggressive agenda of most solid tumors. As such, switching to a glycolytic metabolism may precede the evolution of tumors toward the more aggressive angiogenic and metastatic phenotypes. …

Anti-tumor activity of Herbalzym Vinegar by disrupting cancer cell metabolism

September 4, 2012, Featured in Cancer and Natural Medicines, 0 Comments

Cancer cells must satisfy the metabolic demands of fast-growing cancer within a continually changing microenvironment. The metabolism of cancer is approximately 8 times greater than that of normal cells and the body is constantly overworked trying to feed it. A fundamental difference in sugar metabolism exists between tumor cells found in the hypoxic regions of most solid tumors and the majority of normal cells in the body, which are under oxygen.   

Sugar, or glucose, is brought into cells and converted into useable energy, a molecule called ATP. Another product of this conversion, a molecule called lactate, is then taken out of the cell by specialized transporters. Glucose is metabolized by glycolysis in a multi-step set of reactions resulting in the creation of pyruvate. In normal cells, much of this pyruvate …

« Older Entries   Recent Entries »