Do you want the best cancer fighting bread?
Black seed is the name used for Nigella sativa, an herb in the Ranunculaceae family that produces small black seeds. Nigella sativa is also referred to as nigella, black caraway, and black cumin. Black seed has been an important nutritional flavoring agent and natural remedy for many ailments for centuries in ancient medicine practiced in the Arabian Gulf region, Far East Asia, and Europe. Many active components have been isolated from black seed, including thymoquinone, thymohydroquinone, dithymoquinone, thymol, carvacrol, nigellimine-N-oxide, nigellicine, nigellidine and alpha-hederin. In addition, quite a few pharmacological effects of black seed, its oil, various extracts and active components have been identified to include immune stimulation, anti-inflammation, hypoglycemic, antihypertensive, antiasthmatic, antimicrobial, antiparasitic, antioxidant and anticancer effects.
From here to eternity – the secret of Pharaohs: Therapeutic potential of black cumin seeds and beyond.
Nigella sativa seeds: folklore treatment in modern day medicine.
Anticancer activity of Nigella sativa (black seed) – a review.
Researchers have discovered that thymoquinone can remedy one of the most virulent and difficult to treat cancers: pancreatic cancer. Black Seed extract does this by blocking pancreatic cell growth, and actually enhancing the built-in cellular function that causes programmed cell death, or apoptosis.
Effects of thymoquinone in the expression of mucin 4 in pancreatic cancer cells: implications for the development of novel cancer therapies.
Structure-activity studies on therapeutic potential of Thymoquinone analogs in pancreatic cancer.
Anti-inflammatory effects of the Nigella sativa seed extract, thymoquinone, in pancreatic cancer cells.
Brain cancer is largely a fatal disease. About 60 percent of primary brain tumors are glioblastomas (GBMs). GBMs are considered to be one of the deadliest cancers, characterized by a high proliferative rate, aggressive invasiveness, insensitivity to radio- and chemotherapy and an extremely high recurrence rate. One of the big problems is that GBMs are resistant to therapy as well as a short survival period (the median survival of patients with this disease remains at about one year). There is no “cure” for GBM as yet. Most therapeutic compounds do not cross the blood brain barrier (BBB).
The telomere is a specialized DNA structure present at the ends of chromosomes. Telomeres are essential for chromosome stability. When cells repeatedly divide, this structure becomes progressively shorter. If the telomere structures become too short, the cells die of normal cellular aging. Telomerase (an enzyme) prevents telomere shortening and replicative senescence. The majority of cancers express high levels of telomerase activity. Researchers found that thymoquinone induces telomere shortening by inhibiting telomerase, DNA damage and cell death in glioblastoma cells.
Glioblastoma multiforme: a perspective on recent findings in human cancer and mouse models.
Telomerase inhibition impairs tumor growth in glioblastoma xenografts.
Thymoquinone induces telomere shortening, DNA damage and apoptosis in human glioblastoma cells.
Black seed has also been found to be especially useful in the treatment of breast, lung, prostate, liver, and skin cancer. Researchers have suggested multiple mechanisms for the anticancer effects of black seed and its active compounds, particularly thymoquinone and alpha-hederin (a saponin).
Modulation of apoptosis in human hepatocellular carcinoma (HepG2 cells) by a standardized herbal decoction of nigella sativa seeds, hemidesmus indicus roots and smilax glabra rhizomes with anti- hepatocarcinogenic effects.
Radiosensitization in human breast carcinoma cells by thymoquinone: role of cell cycle and apoptosis.
Thymoquinone up-regulates PTEN expression and induces apoptosis in doxorubicin-resistant human breast cancer cells.
Review on molecular and therapeutic potential of thymoquinone in cancer.
Thymoquinone and cisplatin as a therapeutic combination in lung cancer: In vitro and in vivo.
Studies on molecular mechanisms of growth inhibitory effects of thymoquinone against prostate cancer cells: role of reactive oxygen species.
Nigella sativa modulates splenocyte proliferation, Th1/Th2 cytokine profile, macrophage function and NK anti-tumor activity.
Modes of action of alpha-hederin and thymoquinone, active constituents of Nigella sativa, against HEp-2 cancer cells.
Intracellular glutathione depletion and reactive oxygen species generation are important in alpha-hederin-induced apoptosis of P388 cells.
Alpha-hederin potentiates 5-FU antitumor activity in human colon adenocarcinoma cells.
African descents are more sensitive than European descents to the antitumor compounds α-hederin and kalopanaxsaponin I.
Black seed has a nutty, peppery-tasting flavor. This flavorful small black seed is often used in Jewish rye bread and Armenian string cheese. Known as Kalonji in India, black seed is an ingredient in many Indian spice blends. Black seed is used in the cooking of Lebanese, Serbian, and Armenian cultures. In ancient Egypt, black seed was sprinkled on breads and rolls.
Black seeds are available from specialty spice outlets and Indian or Middle Eastern grocery stores. Black seeds have no American name. Latin: Nigella sativa or Ketzah (Hebrew), in Middle Eastern store you can find it under the name Black Cumin or Black Caraway seed. In Indian stores it is called Black Onion seeds or Kalonji.
Black seed bread has the ability to help stave off cancer and can even help inhibit cancer cell growth or reduce tumor size. Planning ahead is essential to this recipe as the black seed needs to be pre-fermented for 7days. Fermentation releases nutrients and therapeutic agents from the black seed, making them more bio-available for the body: for example sauerkraut contains 20 times more bio-available vitamin C than fresh cabbage.
This is the simplest sourdough bread to make as far as ingredients: Black Seeds, Flour, Water, Original Starter, Salt, Red Palm Oil, and Honey. It may look a bit complicated at first but this is the most basic bread making process that is in use for thousands of years. It takes 9 days from start to finish, but actual cumulative work time is less than an hour.
- ground black seeds: 60 g
- bottled water (no chlorine): 700 g (3 cups)
- unpasteurized wildflower honey (dark amber): 200 g
- starter (AppleZym): 300 g
- unbleached whole wheat flour: 650 g
- unbleached all-purpose flour: 650 g
- red palm oil (or Red Plam-Zym): 16 g
- salt (or sea asparagus salt): 1.5 teaspoons
- BBEGA-Zym (optional): 40 g
- In order to extract the most benefit from your whole black seeds you must grind them fresh, just before using. In a glass jar, mix the ground black seeds with the water and 2 tbsp (20 g) of starter (AppleZym). Store in a dark place for 4 days, shaking the jar well once each day.
- After 4 days, add honey and BBEGA-Zym (optional). Shake the jar well and wait 3 days. Each day, shake the jar well
- Add the remainder of starter (AppleZym) and mix until the starter is fully dissolved
- Add 400 g of whole wheat flour and mix well until smooth. Cover the jar and let stand in room temperature for 8 hours (overnight). When you uncover the jar, it should be bubbly and frothy and smell like sourdough with a hint of alcohol.
- In a large bowl, mix the fermented black seeds with the remainder of the flour, red palm oil, and salt (or sea asparagus salt) until most of the flour has gotten wet. Cover and let stand for 20 min or so.
- Knead the dough for 5 minutes until it is less sticky, smooth and uniform, and can be formed into a ball. Lets stand for 5 minutes and knead some more.
- Split the dough into 4 equal parts (use a scale) and form into 4 balls. Place on slightly oiled baking sheet and let is rise for an hour (You can put it in the oven with the oven light on which makes it 80f or so. To prevent the dough from drying out and developing a skin, also put a baking pan with a few cups of warm water in the oven to make the oven humid)
- After a couple of hours, the dough will raise to almost double its original size.
- Take the dough out and shape it into 4 loaves of whichever shape you like, and place them on baking sheets or special bread forms. Use a sprayer with clean water to keep the bread from drying out and forming a hard skin
- Place the bread into the middle rack of the oven with the light on. Place a small pan with hot water on the bottom rack. Remember what the bread looks like when it went in, because you need to let it triple in volume. Depending of temperature and the four types, it would take from 3 to 5 hours.
- Preheat the oven to 500f. Using a razor blade or a box cutter, make diagonal slashes in the bread, this will allow the bread to expand when baking.
- After 4 minutes open the oven, spray the bread (and the inside of the oven) with water, and close the door as soon as you can. When the bread starts showing signs of browning (little gold patches, typically after 10-15 minutes of baking) turn the temperature down to 430f (if you have convection, switch to convection at 410f).
- Continue to bake until the bread is light mahogany brown but NOT burned. Take the bread out, and let it cool. Sourdough tastes a lot better after 2 hours.
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