Targeting cholesterol metabolism is one route to treating cancer. Part 2

May 10, 2010, Featured in Cancer and Natural Medicines, 0 Comments

We are going to talk about statin cholesterol lowering drugs and their incredible ability to kill outright or sensitize cancer cells to chemo drugs or natural medicines. Anti-cholesterol drugs like statins are useful in the treatment of cancer simply because they block the activity of the enzyme HMG CoA reductase, the enzyme that makes mevalonate in the cell. Mevalonate, a precursor for cholesterol, inhibits prgrammed cell death in cancer cell/leukemia cells. The principal mechanism of any anticancer effects from statin use arises from prolonged lowering of circulating cholesterol and induction of cell cycle arrest. Evidence suggests that prostate cancer, ovarian cancer, lung cancer, colon cancer and leukemia might be particularly sensitive to this intervention. Many statins are available on prescription and are inexpensive, off-patent generic drugs those are immediately available …

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